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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10/2000 - 01/2001
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: study performed according to GLP and OECD guidelines
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl 4-methyloxazole-5-carboxylate
EC Number:
243-848-9
EC Name:
Ethyl 4-methyloxazole-5-carboxylate
Cas Number:
20485-39-6
Molecular formula:
C7H9NO3
IUPAC Name:
ethyl 4-methyl-1,3-oxazole-5-carboxylate

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesame oil
Doses:
2000 mg/kg
No. of animals per sex per dose:
5 per sex per dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw

Any other information on results incl. tables

no other remarks

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 of Oxazolester in the acute oral toxicity study in rats of both sexes was estimated to be greater than 2000 mg/kg.
Executive summary:

The LD50 of Oxazolester in the acute oral toxicity study in rats of both sexes was estimated to be greater than 2000 mg/kg. Therefore, the study was finished as limit test.