Ethyl 4-methyloxazole-5-carboxylate

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10/2000 - 12/2000

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: study performed according to OECD and GLP guidelines

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2000

Report date:

2000

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl 4-methyloxazole-5-carboxylate

EC Number:

243-848-9

EC Name:

Ethyl 4-methyloxazole-5-carboxylate

Cas Number:

20485-39-6

Molecular formula:

C7H9NO3

IUPAC Name:

ethyl 4-methyl-1,3-oxazole-5-carboxylate

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

24 h

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

24 h

Dose descriptor:

NOELR

Effect conc.:

150 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 2

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

333 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 290 - 381 mg/l

Effect concentrations 3

Duration:

24 h

Dose descriptor:

EC100

Effect conc.:

680 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Any other information on results incl. tables

no remarks

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

NOEL 24 h: 150 mg/l
24h EC 50: 333 mg/l
24h EC100: 680 mg/l

Executive summary:

A range-finding test was followed by a final EC50 test performed under static conditions for 24 hours of exposure. The range-finding test showed a 24 EC50 value between 100 and 1000 mg/l.

In the final EC50 test Daphnia were therefore exposed for a maximum of 24 hours to 8 different concentrations (1000, 680, 460, 320, 220, 150, 100, 0 mg/l)

The study included a blank-control. The test was performed in quadruplicate with 5 daphnia

per vessel. The 24h EC50 was determined to 333 mg/l (95% CL: 290 - 381 mg/l)

24 h EC50 (reference substance) = 1.81 mg/l