Registration Dossier
Registration Dossier
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EC number: 220-489-6 | CAS number: 2783-17-7
Endpoint summary
Administrative data
Description of key information
in literature, some data on skin sensitisation is present.
However, as the substance is classified as skin corrosive, cat. 1, no study is performed.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
available literature data:
Title: Acute Toxicity Studies with l,12-Dodecanediamine (DDA)
Year Study Completed: These studies were conducted in 1987-1988.
Author(s): William J. Brock
Affiliation/Address: Haskell Laboratory for Toxicology and Industrial Medicine,
E. I. du Pont de Nemours and Company, P. O. Box 50, Elkton Road, Newark, DE 19714
Dermal Sensitization: Ten Duncan-Hartley guinea pigs were injected (0.1 mL) ID
with a 1% solution of DDA in saline once a week for 4 weeks. Two weeks after
the last injection, the animals were challenged by topical application with 0.4%
and 4% DDA. Dermal responses were scored (1) at 24 and 48 hours after
challenge. DDA produced a sensitization response in 7/10 animals at a
concentration of 4%. No sensitization response was observed at 0.4%.
Assessment of literature data:
For the challenge dose with 4% DDA a pH of ca. 11.9 can be assumed based on general formula on acid-base-chemistry.
Therefore it can be assumed that topical application can also lead to irritation based on the basic nature of the solution.
As there are no results for control animals reported and the lower challenge dose did not result in any reported effects,
the reported effects cannot be related to sensitive properties clearly.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The substance is classified as skin corrosive and the cited study information on skin sensitisation is not conclusive.
Based on the corrosivity, it is concluded that the information is conclusive but not sufficient for classifiaction as skin sensitisation.
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