Potassium niobate

Repeated dose toxicity: other routes

Administrative data

Endpoint:

repeated dose toxicity: other route

Remarks:

Intraperitoneal

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1965, July - August

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

publication

Title:

The toxicity of Niobium salts

Author:

Downs W.L. et al.

Year:

1965

Bibliographic source:

American Industrial Hygiene Association Journal, 26:4, 337 - 346

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

- Principle of test: To investigate the acute and sub-acute toxicity of Potassium Niobate
- Short description of test conditions: Fours groups of five male rats each were given daily intraperitoneal injections of an aqueous solution of potassium niobate (50 mg / ml) at doses of 10, 29, 57 and 95 mg Nb/kg. A fifth group was injected with a solution of KOH (0.27 M) at a dose of 5 ml / kg and served as control.
- Parameters analysed / observed: mortality, gross pathology, histopathology

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Potassium niobate

EC Number:

234-744-4

EC Name:

Potassium niobate

Cas Number:

12030-85-2

Molecular formula:

K.NbO3

IUPAC Name:

niobium(5+) potassium trioxidandiide

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source of test material: Union Carbide Metals Co., Niagara Falls, N.Y.

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

Average weight: 200-224 g

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

water

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

15 days

Frequency of treatment:

Daily

Doses / concentrations

Doses / concentrations 1

Dose / conc.:

10 other: mg Nb / kg

Doses / concentrations 2

Dose / conc.:

29 other: mg Nb / kg

Doses / concentrations 3

Dose / conc.:

57 other: mg Nb / kg

Doses / concentrations 4

Dose / conc.:

95 other: mg Nb / kg

No. of animals per sex per dose:

4 groups of 5 male rats per dose

Control animals:

yes

Examinations

Observations and examinations performed and frequency:

BODY WEIGHT: Yes
- Time schedule for examinations: Not specified

Sacrifice and pathology:

GROSS PATHOLOGY: Yes

Results and discussion

Results of examinations

Clinical signs:

not specified

Mortality:

mortality observed, treatment-related

Description (incidence):

- All rats survived the lowest dose of 10 mg / kg and only one control rat died.
- All rats given the highest dose died within the first four days and two rats given doses of 57 Nb / kg died

Body weight and weight changes:

effects observed, treatment-related

Description (incidence and severity):

- Repeated injections of potassium niobate resulted in a decrease in body weight. At the lowest dose (19 mg Nb / kg) an average gain, in body weight, of only 9 g was observed whereas the control rats gained an average of 36 g during the 15 day period.
- The rats receiving repeated doses of 29 mg Nb / kg showed a slight decrease in weight while a marked weight loss was observed in the rats given doses of 57 mg NB / kg or greater.

Food consumption and compound intake (if feeding study):

not examined

Food efficiency:

not examined

Water consumption and compound intake (if drinking water study):

not examined

Ophthalmological findings:

not examined

Haematological findings:

not examined

Clinical biochemistry findings:

not examined

Urinalysis findings:

not examined

Behaviour (functional findings):

not examined

Immunological findings:

not examined

Organ weight findings including organ / body weight ratios:

not examined

Gross pathological findings:

effects observed, treatment-related

Description (incidence and severity):

- Gross examination revealed pale and enlarged kidneys in the rats given the highest dose. Mean weight was 3.5 g which is considerably higher than the mean value of 1.9 g for control rats.

Neuropathological findings:

not examined

Histopathological findings: non-neoplastic:

not examined

Histopathological findings: neoplastic:

effects observed, treatment-related

Description (incidence and severity):

The kidneys of four of the five rats receiving the lowest dose showed evidence of slight renal damage with scattered tubules containing precipitated pigment associated with epithelial proliferation. No frank necrosis was seen. Kidneys from the three rats which received 11 doses of 29 mg Nb/kg showed marked renal damage. This injury was characterized by the presence of a yellow granular pigment in many tubular lumina and in the cells lining the tubules. Renal tubular necrosis, purulent and hyaline casts, and extensive regenerative changes were frequently seen. Similar changes were noted in the kidneys of one rat given five doses of 57 mg Nb/kg and in two rats which received three doses of 95 mg Nb/kg. No abnormalities were observed in the kidneys of the control rats.

Effect levels

Key result

Dose descriptor:

LOAEL

Effect level:

10 mg/kg bw/day (nominal)

Based on:

test mat.

Sex:

male

Basis for effect level:

body weight and weight gain

gross pathology

Applicant's summary and conclusion

Conclusions:

In an intraperitoneal toxicity study, the test item was administered at doses of 10, 29, 57 and 95 mg / kg bw on four groups of 5 male Wistar rats each, daily for 15 days. The effects included decrease in body weight, renal injury and increased mortality.

Executive summary:

In an intraperitoneal toxicity study, the test item was administered at doses of 10, 29, 57 and 95 mg / kg bw on four groups of 5 male Wistar rats each, daily for 15 days. The effects included decrease in body weight, renal injury and increased mortality.