Registration Dossier
Registration Dossier
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EC number: 234-744-4 | CAS number: 12030-85-2
Endpoint summary
Administrative data
Description of key information
Data describing the acute aquatic toxicity of potassium niobate to aquatic organisms is based on read-across from the structural analogues niobium pentachloride and potassium chloride. Studies are available for invertebrates and algae. For details and justification of read-across please refer to the attached report in section 13 of IUCLID.
The study by Heisterkamp (2015) for the assessment of acute toxicity to Daphnia magna was conducted in accordance with OECD guideline 202. The 48-h acute toxicity of niobium pentachloride to Daphnia magna was assessed under semi-static conditions at nominal concentrations ranging between 889 and 4500 mg/L. The 48-hour EL50 was 1498 mg/L. The 48-h NOELR was 889 mg/L and the LOELR was 1333 mg/L.
The second study with KCl, a peer-reviewed publication from Mount et al. (1999), revealed in a static 48-h acute toxicity test on Daphnia magna and Ceriodaphnia dubia EC50 values of 660 mg/L and 630 mg/L, respectively.
Analogue to the assessment of aquatic invertebrates, one study each on NbCl5 and KCl was used in the assessment of the toxicity of KNbO3 to aquatic algae:
The growth inhibition of niobium pentachloride to cultures of Pseudokirchneriella subcapitata after 72 h was investigated in accordance with OECD guideline 201 at nominal concentrations ranging between 125 and 2000 mg/L. The ErL50 after 72-h was 533 mg/L.
The peer reviewed publication from Patrick et al. (1968) reports effects of KCl on the diatome Nitzscheria linearis. The 120-h EC50 is reported to 1337 ppm (equaling about 1337 mg/L). In a worst-case approach this value is set equla to the 72-h EC50.
For both endpoints, the respective key value for chemical safety assessment is derived by calculating the EC50 value of KNbO3 for combined effects of niobium and potassium ions upon dissolution of the test substance KNbO3 in water. Thus, the calculated EC50 (48-h) and ErC50 (72-h) for effects of KNbO3 on aquatic invertebrates and freshwater algae are approximately 735 mg/L and 976 mg/L, respectively.
Additional information
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