Registration Dossier
Registration Dossier
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EC number: 247-570-9 | CAS number: 26266-63-7
Endpoint summary
Administrative data
Description of key information
The oral toxicity of tetrahydrophthalic Anhydride (THPA) over an exposure period of 4 consecutive weeks and recovery from any potential treatment-related effects over a period of 2 consecutive weeks has been investigated. Methods were in accordance with OECD/EU test guidelines. No clinical signs of toxicity were observed and no significant variations were observed in haematology and clinical chemistry parameters. The high dose of 600 mg/kg/day was considered to be the No Observed Adverse Effect Level (NOAEL) for systemic toxicity and the low dose of 100 mg/kg/day was considered to be the No Observed Adverse Effect Level (NOAEL) for local effects.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 600 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- System:
- gastrointestinal tract
- Organ:
- stomach
Additional information
Justification for classification or non-classification
Those effects of treatment observed following repeated administration of the substance at high doses are not of sufficient severity to justify classification
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