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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
genetic toxicity in vivo
Remarks:
Type of genotoxicity: other: chromosomal damage
Type of information:
experimental study
Remarks:
the registered substance and 76-22-2 are sharing the similar chemical structure and classification, so we generate the studies of the registered substance by read-across
Adequacy of study:
key study
Study period:
1999
Reliability:
2 (reliable with restrictions)
Justification for type of information:
source substance and target substance are sharing very similar structural formula

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1999

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Food and Drug Administration (FDA) Good Laboratory Practice Regulations for Nonclinical Studies (GLP Guidelines)
GLP compliance:
yes
Type of assay:
micronucleus assay

Test material

Constituent 1
Chemical structure
Reference substance name:
(+)-bornan-2-one
EC Number:
207-355-2
EC Name:
(+)-bornan-2-one
Cas Number:
464-49-3
Molecular formula:
C10H16O
IUPAC Name:
1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
Test material form:
solid

Test animals

Species:
mouse
Strain:
B6C3F1
Sex:
male/female
Details on test animals or test system and environmental conditions:
The NTP also routinely conducts peripheral blood micronucleus tests on mice that are treated in the 13-week toxicity studies as part of the bioassay program

Administration / exposure

Route of administration:
other: inhalation, dosed-feed, drinking water, oral gavage, skin painting
Vehicle:
Ethanol
Duration of treatment / exposure:
90 Days
No. of animals per sex per dose:
there are normally 5 male animals per treatment group

Examinations

Statistics:
in the micronucleus test, animals are treated with a chemical and then the frequency of micronucleated cells is determined at some specified time after treatment. If a treated group of animals shows significantly higher frequencies of micronucleated cells than do the untreated control animals, then the chemical is considered to be capable of inducing structural and/or numerical chromosomal damage.

Results and discussion

Test results
Key result
Sex:
male/female
Genotoxicity:
negative
Toxicity:
no effects
Additional information on results:
After a 24-hour exposure to the camphor, no dose-group of either sex showed a significant increase in micronucle iscompared to the control.

Applicant's summary and conclusion