Registration Dossier
Registration Dossier
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EC number: 258-658-1 | CAS number: 53605-94-0
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 June to 22 July 2013
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- The carbon content of n-Butyl-3-hydroxybutyrate was calculated based on information provided by the sponsor and has a value of 60%
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- Cambridge Seage Treatment Works, Cowley Road, Cambridge CB24 8SW, UK
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 50.16 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Reference substance:
- acetic acid, sodium salt
- Test performance:
- Test met all validlity criteria and the reference material degradation was 87% on day 29.
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 83
- Sampling time:
- 28 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 91
- Sampling time:
- 29 d
- Details on results:
- 10% degradation was achieved after approximately 1.5 days, and 60% was reached on day 8, n-Butyl-3-hydroxybutryate therefore easily achieved the 10-day window.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- n-Butyl-3 -hydroxybutyrate gave a positive result (>60% degradation relative to the ThCO2 value) with a maximum of 91% recorded on day 29. It may therefore, be concluded that there is a potential for biodegradation under environmental conditions.
- Executive summary:
A Ready Biodegradability test was conducted with n-Butyl-3 -hydroxybutyrate following OECD 301B (CO2 Evolution Test). The test material was reported to meet the 10 -day window criterion with 10% degradation on approximately 1.5 days and 60% by day 8. The final percent degradation was 83% on day 28 and 91% on day 29. Therefore, n-Butyl-3 -hydroxybutyrate is considered to be readily biodegradable.
Reference
Description of key information
n-Butyl-3 -hydroxybutyrate gave a positive result (>60% degradation relative to the ThCO2 value) with a maximum of 91% recorded on day 29. It may therefore, be concluded that there is a potential for biodegradation under environmental conditions.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
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