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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
three-generation reproductive toxicity
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1995
Report date:
1995

Materials and methods

Test guideline
Guideline:
other: unknown
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Phloroglucinol
EC Number:
203-611-2
EC Name:
Phloroglucinol
Cas Number:
108-73-6
Molecular formula:
C6H6O3
IUPAC Name:
benzene-1,3,5-triol

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: feed
Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
221 days (first generation), 105 days (second generation), 115 days (third generation)
Doses / concentrations
Remarks:
Doses / Concentrations:
0.00%, 0.15%, 0.31%, 0.62%
Basis: nominal in diet
No. of animals per sex per dose:
20

Results and discussion

Results: P0 (first parental generation)

General toxicity (P0)

Clinical signs:
no effects observed
Mortality:
no mortality observed

Reproductive function / performance (P0)

Reproductive function: oestrous cycle:
no effects observed

Effect levels (P0)

Key result
Dose descriptor:
conc. level:
Effect level:
> 620 ppm (nominal)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: no effects observed at the highest dose of 0.62%
Remarks on result:
other: see attached study details

Results: P1 (second parental generation)

General toxicity (P1)

Clinical signs:
no effects observed
Mortality:
no mortality observed

Reproductive function / performance (P1)

Reproductive function: oestrous cycle:
no effects observed

Effect levels (P1)

Key result
Dose descriptor:
conc. level:
Effect level:
> 620 ppm (nominal)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: no effects observed at the highest dose level of 0.62 %
Remarks on result:
other: see attached study results

Results: F1 generation

General toxicity (F1)

Clinical signs:
no effects observed
Mortality / viability:
no mortality observed

Effect levels (F1)

Key result
Dose descriptor:
conc. level:
Generation:
F1
Effect level:
> 620 ppm (nominal)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: no effects observed at the highest dose level of 0.62%
Remarks on result:
other: see attached study results

Overall reproductive toxicity

Key result
Reproductive effects observed:
no
Lowest effective dose / conc.:
620 ppm (nominal)
Treatment related:
no

Applicant's summary and conclusion