Registration Dossier
Registration Dossier
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EC number: 264-355-5 | CAS number: 63589-47-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Bis(2-ethylhexyl)zinkdithiophosphat [MAK Value Documentation in German language, 2004]
- Author:
- The MAK Collection for Occupational Health and Safety
- Year:
- 2 012
- Bibliographic source:
- Bis(2-ethylhexyl)zinkdithiophosphat [MAK Value Documentation in German language, 2004]. The MAK Collection for Occupational Health and Safety. 1–14. 2012.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- To assess the ocular irritation potential of chemical bis (2-ethylhexyl) zinc dithiophosphate (CAS No: 4259-15-8) in accordance with OECD Test Guideline 405.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- zinc bis[O,O–bis(2–ethylhexyl)] bis(dithiophosphate))
- Cas Number:
- 4259-15-8
- Molecular formula:
- C16H35O2PS2.1/2Zn
- IUPAC Name:
- zinc bis[O,O–bis(2–ethylhexyl)] bis(dithiophosphate))
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report):zinc bis[O,O–bis(2–ethylhexyl)] bis(dithiophosphate))
- Molecular formula:C16H35O2PS2.1/2Zn
- Molecular weight :772.487 g/mole
- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):zinc bis[O,O–bis(2–ethylhexyl)] bis(dithiophosphate))
- Molecular formula:C16H35O2PS2.1/2Zn
- Molecular weight :772.487 g/mole
- Substance type:Organic
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 100%
- Duration of treatment / exposure:
- Single exposure
- Observation period (in vivo):
- 96 hours
- Number of animals or in vitro replicates:
- No data available
- Details on study design:
- No data available
Results and discussion
In vivo
Results
- Irritation parameter:
- other:
- Basis:
- mean
- Time point:
- other: 96 h
- Score:
- 23.5
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Eye irritation was observed in treated rabbits
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The mean Primary irritation index scores after 96 hour was 23.5 out of maximum score of 110. Hence, bis (2-ethylhexyl) zinc dithiophosphate (CAS No: 4259-15-8) can be considered to be irritating to rabbit eyes.
- Executive summary:
An eye irritation study was carried out on rabbits to assess the eye irritation potential of chemical thebis (2-ethylhexyl) zinc dithiophosphate (CAS No: 4259-15-8) in accordance with OECD Test Guideline 405.
During this test, theundiluted test chemicalwas instilled into eyes of each rabbits. The rabbits were observed and scored for signs of irritation at 96 hours.
The meanPrimary irritation indexscores after 96 hour was 23.5 out of maximum score of 110.Hence,bis (2-ethylhexyl) zinc dithiophosphate (CAS No: 4259-15-8)can be considered to irritating to rabbit eyes.
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