Registration Dossier
Registration Dossier
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EC number: 264-355-5 | CAS number: 63589-47-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute Dermal Toxicity of N,N-dimethyl-p-toluidine (99-97-8)
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank), US national Library of Medicine, 2017
- Reference Type:
- secondary source
- Title:
- SCREENING-LEVEL HAZARD CHARACTERIZATION Monocyclic Aromatic Amines Category
- Author:
- U.S. Environmental Protection Agency Hazard Characterization Document
- Year:
- 2 009
- Bibliographic source:
- U.S. Environmental Protection Agency Hazard Characterization Document. September,2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as metioned below
- Principles of method if other than guideline:
- Acute Dermal Toxicity of N,N-dimethyl-p-toluidine (99-97-8) in rabbits.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- N,N-dimethyl-p-toluidine
- EC Number:
- 202-805-4
- EC Name:
- N,N-dimethyl-p-toluidine
- Cas Number:
- 99-97-8
- IUPAC Name:
- N,N,4-trimethylaniline
- Details on test material:
- IUPAC name: N,N-dimethyl-p-toluidine
Molecular formula: C9H13N
Molecular weight: 135.209 g/mole
Smiles: c1(N(C)C)ccc(C)cc1
InChI: 1S/C9H13N/c1-8-4-6-9(7-5-8)10(2)3/h4-7H,1-3H3
Constituent 1
- Specific details on test material used for the study:
- IUPAC name: N,N-dimethyl-p-toluidine
Molecular formula: C9H13N
Molecular weight: 135.209 g/mole
Smiles: c1(N(C)C)ccc(C)cc1
InChI: 1S/C9H13N/c1-8-4-6-9(7-5-8)10(2)3/h4-7H,1-3H3
Substance type:Organic
Physical state:Clear colorless liquid
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 2000 mg/kg-bw
- No. of animals per sex per dose:
- Total = 10 (5/sex/dose)
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No Mortality observed
- Mortality:
- No Mortality observed at 2000 mg/kg-bw
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be > 2000 mg/kg bw, when male and female New Zealand White rabbits were treated with N,N-dimethyl-p-toluidine (99-97-8) by dermal application.
- Executive summary:
The acute dermal toxicity of N,N-dimethyl-p-toluidine (99-97-8) was tested in 10 male and female New Zealand White rabbits at the concentration of 2000 mg/kg bw. No mortality was observed at 2000 mg/kg bw. Therefore, LD50 was considered to be > 2000 mg/kg bw, when male and female New Zealand White rabbits were treated with N,N-dimethyl-p-toluidine by dermal application.
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