Registration Dossier
Registration Dossier
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EC number: 226-408-0 | CAS number: 5395-50-6
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Human Health Tier II Assessment For N-Methylol imidazolidones
- Author:
- Accelerated Assessment of Industrial Chemicals in Australia (IMAP)
- Bibliographic source:
- https://www.nicnas.gov.au/chemical-information/imap-assessments
Materials and methods
Test material
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Doses / concentrationsopen allclose all
- Dose / conc.:
- 125 mg/kg bw/day
- Dose / conc.:
- 405 mg/kg bw/day
- Dose / conc.:
- 1 215 mg/kg bw/day
Results and discussion
Results: maternal animals
General toxicity (maternal animals)
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- 2 each in mid and high dose
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- reduced b.w. in mid and high dose
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- 125 mg/kg bw/day
- Basis for effect level:
- mortality
Maternal abnormalities
- Abnormalities:
- no effects observed
Results (fetuses)
- Fetal body weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- reduced, secondary to maternal toxicity
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- 405
- Based on:
- test mat.
- Basis for effect level:
- fetal/pup body weight changes
Fetal abnormalities
- Abnormalities:
- no effects observed
Overall developmental toxicity
- Developmental effects observed:
- no
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
