Registration Dossier
Registration Dossier
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EC number: 210-535-3 | CAS number: 617-86-7
Endpoint summary
Administrative data
Description of key information
The key study for skin irritation found triethylsilane to be not irritating to the skin (OECD Guideline 404, GLP compliant, LPT 2002b).
The key study for eye irritation found triethylsilane to be not irritating to the eye (OECD Guideline 405, GLP compliant, LPT, 2002c).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The key study for skin irritation, conducted according to OECD 404 and in compliance with GLP, grade 1 erythema was observed in 2 male rabbits up to 72 hour observation and in one male rabbit up to 24 hours. Skin induration was noted in 2 animals. It was concluded that triethylsilane is not irritating to skin following semi-occlusive exposure for 4 hours (LPT, 2002b).
In the key study for eye irritation, conducted according to OECD 405 and in compliance with GLP, triethylsilane was found to be not irritating to rabbit eyes following a single instillation in the eyes of three female rabbits (LPT, 2002c).
The skin and eye irritation tests on analogue substance, tetramethylsilane (CAS 75-76-3) are included in support of the read-across justification, as data for this substance are used as key data for skin sensitisation, repeated dose toxicity, genetic toxicity and toxicity to reproduction.
Justification for classification or non-classification
Based on the available in vivo data, triethylsilane does not require classification for skin or eye irritation according to Regulation (EC) No 1272/2008.
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