Ethanethiol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

No data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study was classified as reliable with restrictions because it was an acceptable, well-documented study report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: 49CFR173.240

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethanethiol

EC Number:

200-837-3

EC Name:

Ethanethiol

Cas Number:

75-08-1

Molecular formula:

C2H6S

IUPAC Name:

ethanethiol

Details on test material:

ethyl mercaptan, purity not specified
- Name of test material (as cited in study report): ethyl mercaptan (Ethanethiol)
- Physical state: liquid
- Other: clear and colourless

Test animals

Species:

rabbit

Strain:

other: albino

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): 0.845 g/mL

Duration of treatment / exposure:

4 hour(s)

Observation period:

3 days

Number of animals:

6

Details on study design:

TEST SITE
- Area of exposure: trunk
- Type of wrap if used: gauze patch

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: 4 hours

Score:

2

Max. score:

4

Reversibility:

fully reversible within: overnight

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

other: 4 hours

Score:

0

Max. score:

4

Any other information on results incl. tables

Initial skin contact evoked a mild pain reaction, when exposures were  terminated at four hours, moderate erythema (score 2) was present at all  of the treated sites; this
dissipated completely overnight. No other signs of skin irritancy could be discerned.

Applicant's summary and conclusion

Interpretation of results:

slightly irritating

Remarks:

Migrated information (Not Classified) Criteria used for interpretation of results: EU

Conclusions:

Ethanethiol was found to be slightly irritating to the skin of rabbits, but this irritation was not sufficient to trigger classification (Latven, 1977).

Executive summary:

In a key primary dermal irritation study (Latven, 1977), six albino rabbits were dermally exposed to 0.5 millilitres of ethanethiol under occlusive wrap for 4 hours. The animals were subsequently observed for a period of 3 days.

Initial skin contact was found to elicit a mild pain reaction and moderate erythema (2) was observed at all treated sites at the end of the 4-hour exposure period. However, erythema was reversible and observed to have dissipated completely by the following morning. No other signs of treatment-related irritation or toxicity were observed. Ethanethiol was not considered to be a dermal irritant.

This study received a Klimisch score of 2 and is classified as reliable with restrictions because it was an acceptable study report which meets basic scientific principles.