Registration Dossier
Registration Dossier
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EC number: 200-837-3 | CAS number: 75-08-1
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Biodegradation in water (screening tests): 0% biodegradation in 28 days
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Clarke (2011) is a GLP compliant ready biodegradability, manometric respirometry test conducted according to OECD guideline 301F. A re-inoculation test showed no degradation after 28 days at an initial concentration of 20 mg/L. The study was modified, at the request of the study sponsor, to use soil and activated sludge from a wastewater treatment facility in a composite microbial inoculum. This follows REACH Guidance Chapter R.7b: Endpoint specific guidance, in order to increase the potential for the substance to be biodegraded. Although the study is GLP compliant, the homogeneity, concentration or stability of the test item formulation was not analysed, but this is not believed to have affected the outcome of the study. The study is considered Klimisch 1, reliable without restrictions, and suitable for use as key study for this endpoint. On the basis of this study, ethanethiol is not readily biodegradable.
The key data are supported by Thiebaud (1994), a non-GLP, guideline study, according to OECD 301D (Closed Bottle Test), which was reported as the key study in the OECD HPV SIDS Initial Assessment Report for C2-C4 Aliphatic Thiols at SIAM 30 (April 2010). 27% biodegradation was reported in 28 days.. The study is considered Klimisch 2 (reliable with restrictions) and suitable for use for this endpoint. Only the summary of the study is available and therefore the study cannot be fully evaluated.
Van Leerdam (2006) is a published paper. The study is non-GLP, non-guideline but can be considered reliable and suitable for use as supporting information for this endpoint. The study measured the sulphide concentrations in methanol and acetate experiments. The toxicity of ethanethiol and propanethiol was tested by adding them to anaerobic granular sludge that converts methanol, acetate or hydrogen.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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