Hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, >5% n-hexane

Endpoint summary

Description of key information

Oral LD50 (rat) > 5840 mg/kg bw
Dermal LD 50 (rat) > 2920 mg/kg bw
Inhalative LD50 (rat) > 25200 mg/m³

Additional information

Oral

 

There are no data available on the acute oral toxicity of hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, > 5% n-hexane. However, there are reliable data available for another category member. Thus, read-across was conducted based on a category-approach.

The acute oral toxicity of hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics was tested following a standard method. Two male and two female rats were exposed to 1, 2, 4, or 8 mL/kg of undiluted test substance orally by gavage. The animals were then observed for the next 9 days for mortality. No animals of either sex died during the study. The LD₅₀was > 8 mL/kg for both male and female rats. Based on the density given in the study report, the LD₅₀was calculated to be higher than approx. 5840 mg/kg bw (Shell Chemicals, 1977).

 

Inhalation

 

There are no data available on the acute toxicity of hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, > 5% n-hexane, after inhalative exposure. However, there are reliable data available for another category member. Thus, read-across was conducted based on a category-approach.

The acute toxicity of hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, < 5% n-hexane, upon inhalation was tested in rats exposed at 25200 mg/m³ for 4 h. There were no deaths during the study. Besides restless behaviour, increase in respiration rate during the first 15 minutes, partial closing of the eyes and slightly reduced food consumption on day 1 post-exposure, no signs of toxicity were observed. The LC₅₀value was therefore greater than 25200 mg/m³ air (Shell Chemicals, 1988).

 

Dermal

 

There are no data available on the acute dermal toxicity of hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, > 5% n-hexane. However, there are reliable data available for another category member. Thus, read-across was conducted based on a category-approach.

Hydrocarbons, C7-C9, n-alkanes, isoalkanes, cyclics were applied on the shaved backs of Charles River CD rats (2/sex/dose) at 1, 2, and 4 mL/kg bw (730, 1460, and 2920 mg/kg bw) for 24 hours in accordance with the method of Noakes and Sanderson, 1969 [Br. J Indust. Med 26:59-64] (similar to OECD 402). No deaths or clinical signs were observed. The LD₅₀was greater than 4 mL/kg bw, corresponding to 2920 mg/kg bw (Shell Chemicals, 1977).

Justification for classification or non-classification

Based on read-across within a category approach, the available data on the acute toxicity of hydrocarbons, C6-C7, n-alkanes, isoalkanes, cyclics, > 5% n-hexane are conclusive but not sufficient for classification. However, acute exposure may result in non-lethal narcotic effects and hydrocarbons poses aspiration hazard.

DSD: R65-67

 

CLP: Aspiration Toxicity Category 1, STOT Single Exposure Category 3 (narcosis)