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EC number: 453-460-3 | CAS number: -
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 December 2015 to 11 December 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0.009 Pa
- Temp.:
- 40 °C
- Vapour pressure:
- 0.006 Pa
- Temp.:
- 70 °C
- Vapour pressure:
- 0.006 Pa
- Temp.:
- 150 °C
- Vapour pressure:
- 0.085 Pa
- Conclusions:
- The vapour pressure of the test item was determined to be 9.08 x 10E-03 Pa at 25 °C (298 K), 6.49x 10E-03 Pa at 40 °C (313 K), 5.75x 10E-03 Pa at 70 °C (343 K) and 8.50x 10E-02 Pa at 150 °C (423 K).
- Executive summary:
GUIDELINE
The determination was carried out using a vapour pressure balance and a procedure designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.
RESULTS
The vapour pressure of the test item was determined to be 9.08 x 10E-03 Pa at 25 °C (298 K), 6.49x 10E-03 Pa at 40 °C (313 K), 5.75x 10E-03 Pa at 70 °C (343 K) and 8.50x 10E-02 Pa at 150 °C (423 K).
- Endpoint:
- vapour pressure
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted calculation method SPARC online calculator.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- Calculation based on SPARC online calculator http://ibmlc2.chem.uga.edu/sparc/, University of Georgia, USA.
- GLP compliance:
- no
- Remarks:
- Calculation
- Type of method:
- other: estimated by calculation
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: Calculated for C25H44O8
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: 7.38E-16 Pa calculated for C33H60O8
- Endpoint:
- vapour pressure
- Type of information:
- other: Expert statement
- Adequacy of study:
- supporting study
- Study period:
- 24 March 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Valid and conclusive statement
- Conclusions:
- Two valid methods were used at differing times to determine vapour pressure of two different test materials. The difference in results is not an indicator that there is an actual difference in their vapour pressures, such that one is higher or lower than the other, but is an indication that both test materials have a low vapour pressure.
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2012-10-02 to 2012-12-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- GLP compliance:
- yes
- Type of method:
- effusion method: vapour pressure balance
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- The vapour pressure of the test item has been determined to be 3.2E-06 Pa at 25°C
- Executive summary:
Method
The determination was carried out using a procedure designed to be compatible with Method A4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006
Conclusion
The vapour pressure of the test item has been determined to be 3.2E-06 Pa at 25 °C
- Endpoint:
- vapour pressure
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Accepted calculation method. SPARC online calculator.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- Calculation based on SPARC online calculator http://ibmlc2.chem.uga.edu/sparc/, University of Georgia, USA.
- GLP compliance:
- no
- Remarks:
- Calculation
- Type of method:
- other: estimated by calculation
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: Calculation for C30H56O6
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: Calculation for C36H68O6
- Endpoint:
- vapour pressure
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- To register EC453-460-3 under REACH program, a read-across approach for fulfillment of the endpoints has been adopted. EC453-460-3 is an aliphatic ester and fits the description of polyol esters category in HPV program (High Production Volume, US-EPA). The distinguishing feature of polyol esters category is that the fatty acids were linked to one or more of the multiple hydroxyl groups present in the polyol (alcohol portion of ester). The focus of this correspondence is to support read across to EC613-848-7 (target) which provided key studies to determine hazard profile of EC453-460-3 (target), published information on other structurally analogous polyol esters were served as supporting evidence.
- Reason / purpose for cross-reference:
- read-across source
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: Calculated for C25H44O8
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: 7.38E-16 Pa calculated for C33H60O8
- Endpoint:
- vapour pressure
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- To register EC453-460-3 under REACH program, a read-across approach for fulfillment of the endpoints has been adopted. EC453-460-3 is an aliphatic ester and fits the description of polyol esters category in HPV program (High Production Volume, US-EPA). The distinguishing feature of polyol esters category is that the fatty acids were linked to one or more of the multiple hydroxyl groups present in the polyol (alcohol portion of ester). The focus of this correspondence is to support read across to EC613-848-7 (target) which provided key studies to determine hazard profile of EC453-460-3 (target), published information on other structurally analogous polyol esters were served as supporting evidence.
- Reason / purpose for cross-reference:
- read-across source
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- The vapour pressure of the test item has been determined to be 3.2E-06 Pa at 25°C
- Executive summary:
Method
The determination was carried out using a procedure designed to be compatible with Method A4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006
Conclusion
The vapour pressure of the test item has been determined to be 3.2E-06 Pa at 25 °C
- Endpoint:
- vapour pressure
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reason / purpose for cross-reference:
- read-across source
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: Calculation for C30H56O6
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Remarks on result:
- other: Calculation for C36H68O6
Referenceopen allclose all
PRELIMINARY RUN
- Recorded temperatures and mass differences are shown in Table 3.1 (attached) together with mass differences and calculated vapour pressure values.
- Preliminary run vapour pressure data are presented graphically in Figure 3.2 (attached).
DEFINITIVE RUNS
- The direct values of the vapour pressure at 25 °C are shown in Table 3.2 and Figure 3.3 (attached).
-The direct values of the vapour pressure at 40 °C are shown in Table 3.3 and Figure 3.4 (attached).
-The direct values of the vapour pressure at 70 °C are shown in Table 3.4 and Figure 3.5 (attached).
-The direct values of the vapour pressure at 150 °C are shown in Table 3.5 and Figure 3.6 (attached).
- For clarity, incorrect numbering of the table and graph in the study report has been corrected with respect to the definitive run at 150 °C.
- The test item did not change in appearance during the definitive determinations.
See attached document. The test item did not change in appearance under the conditions used in the determination.
See attached document. The test item did not change in appearance under the conditions used in the determination.
Description of key information
The vapour pressure of the test item was determined to be 9.08 x 10E-03 Pa at 25°C (298 K), 6.49x 10E-03 Pa at 40°C (313 K), 5.75x 10E-03 Pa at 70°C (343 K) and 8.50x 10E-02 Pa at 150°C (423 K) (OECD 104 and EU Method A.4).
Key value for chemical safety assessment
- Vapour pressure:
- 0.009 Pa
- at the temperature of:
- 25 °C
Additional information
GUIDELINE
The determination was carried out using a vapour pressure balance and a procedure designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.
RESULTS
The vapour pressure of the test item was determined to be 9.08 x 10E-03 Pa at 25 °C (298 K), 6.49x 10E-03 Pa at 40 °C (313 K), 5.75x 10E-03 Pa at 70 °C (343 K) and 8.50x 10E-02 Pa at 150 °C (423 K).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
