Registration Dossier
Registration Dossier
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EC number: 944-003-3 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18-July-2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction products of sodium sulphide, sulphur, carbon disulphide and potassium hydroxide
- EC Number:
- 944-003-3
- IUPAC Name:
- Reaction products of sodium sulphide, sulphur, carbon disulphide and potassium hydroxide
- Test material form:
- liquid
Constituent 1
In vitro test system
- Test system:
- artificial membrane barrier model
- Vehicle:
- unchanged (no vehicle)
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- 500 uL
- Duration of treatment / exposure:
- Not applicable.
- Duration of post-treatment incubation (if applicable):
- Not applicable.
- Number of replicates:
- 4
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- penetration time (in minutes)
- Run / experiment:
- Mean
- Value:
- 32.18
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: Standard Deviation
- Remarks:
- +/- 0.17
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Executive summary:
In a GLP-compliant OECD 435 Guideline study, the mean time for the test substance to penetrate the biobarrier was 32.18 minutes (+/- 0.17) and was therefore determined to be corrosive to skin and classified as Category 1C (corrosive) based on GHS criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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