Registration Dossier
Registration Dossier
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EC number: 217-110-1 | CAS number: 1742-95-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data is from review article or handbook
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- 1,5-Diaminonaphthalene [MAK Value Documentation, 2013]
- Author:
- The MAK Collection for Occupational Health and Safety
- Year:
- 2 013
- Bibliographic source:
- The MAK Collection for Occupational Health and Safety, pg 1–13, 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Skin irritation test was conducted in rabbits for test chemical 1, 5-Diaminonaphthalene according to OECD Test Guideline 404.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,5-Diaminonaphthalene
- IUPAC Name:
- 1,5-Diaminonaphthalene
- Reference substance name:
- 1,5-naphthylenediamine
- EC Number:
- 218-817-8
- EC Name:
- 1,5-naphthylenediamine
- Cas Number:
- 2243-62-1
- IUPAC Name:
- naphthalene-1,5-diamine
- Test material form:
- other: solid
- Details on test material:
- - Name of test material (as cited in study report): 1,5-Diaminonaphthalene
- Molecular formula: C10H10N2
- Molecular weight: 158.22 g/mol
- Substance type: organic
- Physical state: solid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500mg/ kg body weight
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- No data
- Number of animals:
- No data
- Details on study design:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- no data
- Remarks on result:
- other: Not irritating
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test chemical 1, 5-Diaminonaphthalene (CAS No: 2243-62-1) was observed to be not irritating on rabbits skin.
- Executive summary:
Skin irritation test was performed in rabbits to observe the irritation potential of test chemical 1, 5-Diaminonaphthalene(CAS No: 2243-62-1) according to OECD Test Guideline 404.
The rabbits were exposed to 500mg of test chemical for 4 hours exposure period under semi-occlusion.
Since no known skin irritation effects were observed, the test chemical, 1, 5-Diaminonaphthalene(CAS No: 2243-62-1) was considered as not irritating to rabbits’ skin.
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