Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-995-8 | CAS number: 734-32-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Quantitative Bestimmung von 19-Norsteroiden nach peroraler und sublingualer Applikation von Norandrostendion und Norandrostendiol Eine klinische Studie zum Metabolismus von Nandrolon-Prohormonen
- Author:
- Schrader, Y
- Year:
- 2 007
- Bibliographic source:
- dissertation; Institute for Biochemistry; German Sport University Cologne
Materials and methods
- Objective of study:
- metabolism
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Estr-4-ene-3,17-dione
- EC Number:
- 211-995-8
- EC Name:
- Estr-4-ene-3,17-dione
- Cas Number:
- 734-32-7
- Molecular formula:
- C18H24O2
- IUPAC Name:
- estr-4-ene-3,17-dione
- Test material form:
- other: solid
Constituent 1
Test animals
- Species:
- other: human
- Sex:
- male
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- 100 mg (capsule) dose group: Cmax: 3.6–78.7 ng/ml, tmax: 30 min to 3 h after application;
25 mg (sublingual) dose group: Cmax: 12.5–60.2 ng/ml, tmax: ca 30 min
- Type:
- metabolism
- Results:
- Norandrostendione is metabolised to Nandrolon, Norandrosteron, and Noretiocholanolon
Any other information on results incl. tables
Dose NAD (mg) | Cmax (ng/ml) | tmax (h) | AUC (h*ng/ml) |
100 mg (capsule) | 35.1 (± 27.1) | 1.3 (± 0.8) | 61.0 (± 47.6) |
25 mg (sublingual) | 28.7 (± 15.7) | 0.3 (± 0.1) | 33.9 (± 16.4) |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
