Registration Dossier
Registration Dossier
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EC number: 241-769-4 | CAS number: 17791-81-0
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
The substance can be expected to have a low potential for adsorption due to its low log Kow of < -6.5.
Key value for chemical safety assessment
Additional information
Based on the physicochemical properties the substance can be expected to have a low potential for adsorption (log Kow < -6.5). Therefore, in accordance with column 2 of REACH Annex VIII the study does not need to be conducted.
For completeness, KOC QSAR data have been derived from EPI Suite: First Order Molecular Connectivity Index log Koc was calculated to be 18.2456 and KOC to be 1E+010 L/kg, respectively. Using the KOW method the log KOC was calculated to be -1.5115 and the KOC to be 0.03079 L/kg, respectively. Strongly different Koc values were calculated with the MCI and Kow mehtod. The calculated log Koc using the log Kow method was regarded as more reliable because this value based on a measured log Kow of the substance. However, the QSAR data showed that the test substance is not within the applicability domain and therefore the calculated values should be regarded with caution.
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
For the assessment of 4,4'-[1,2-ethenediylbis[(3-sulfo-4,1-phenylene)imino[6-(4-morpholinyl)-1,3,5-triazine-4,2-diyl]imino]]bis[5-hydroxy-6-(2-phenyldiazenyl)-2,7-naphthalenedisulfonic acid] hexasodium salt (Q)SAR results were used for Adsorption/desorption. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment. Therefore, further experimental studies on adsorption / desorption are not provided.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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