Registration Dossier
Registration Dossier
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EC number: 500-199-9 | CAS number: 68183-39-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance is an UVCB generated by the reaction of glycerol, propane-1,3-diol and trimellitic anhydride. It is expected that the starting materials or their hydrolysis products are released in the course of metabolism. Esterases present in the skin, in the interstinal tissues and in liver and plasma can efficiently cleave similar esters.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 1
- Absorption rate - inhalation (%):
- 100
Additional information
The dermal absorption has been modeled according to Fitzpatrick et al.. The log Kp calculated with a mol wt. of 920 and a logKow of 0.3 is -12.2 indicating a marginal potential for skin penetration.
D. Fitzpatrick, J. Corish, B. Hayes: Modelling skin permeability in risk assessment–the future. Chemosphere 55 (2004) 1309–1314
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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