Registration Dossier
Registration Dossier
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EC number: 203-571-6 | CAS number: 108-31-6
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Only secondary literature, no details available.
- Qualifier:
- according to guideline
- Guideline:
- other: Prolonged toxicity test according to a proposal of the German Federal Environmental Agency, Berlin (February 1984)
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 77 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- reproduction
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- reproduction
- Validity criteria fulfilled:
- not specified
- Conclusions:
- NOEC (Daphnia magna, 21 d) = 10 mg/L (reproduction rate)
EC50 (Daphnia magna, 21 d) = 77 mg/L (reproduction rate) - Executive summary:
The 21-day chronic toxicity of maleic anhydride to Daphnia magna was studied. The 21-day EC50 based on reproduction was 77 mg/L. The 21-day NOEC based on reproduction rate was 10 mg/L.
Based on the limited detail of information available, the reliability of this study cannot be assessed and it is classified as supplementary.
Results synopsis
EC50: 77 mg/L
NOEC: 10 mg/L
Endpoint(s) effected: Reproduction rate
Reference
Description of key information
NOEC (Daphnia magna, 21 d) = 10 mg/L (reproduction rate)
EC50 (Daphnia magna, 21 d) = 77 mg/L (reproduction rate)
Key value for chemical safety assessment
Additional information
A study investigating the long-term toxicity of maleic anhydride to Daphnia magna is published. The study was a performed as a prolonged toxicity test according to a proposal of the German Federal Environmental Agency (1984). The reproduction of Daphnia magna was determined within 21 days of exposure to the substance. A NOEC of 10 mg/L and an EC50 of 77 mg/L were determined (Hüls AG, 1988).
Based on the limited detail on information available for this study, the study is considered not reliable and is hence not used in the chemical safety assessment of maleic anhydride.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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