Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
203-571-6
CAS no.:
108-31-6
Index number:
Molecular formula:
C4H2O3
SMILES:
O=C1OC(=O)C=C1
InChI:
InChI=1S/C4H2O3/c5-3-1-2-4(6)7-3/h1-2H
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
42
Of which contain:
3 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP13) approved by the European Union, this substance causes severe skin burns and eye damage, causes damage to organs through prolonged or repeated exposure, is harmful if swallowed, causes serious eye damage, may cause an allergic skin reaction and may cause allergy or asthma symptoms or breathing difficulties if inhaled.

Breakdown of all 3858 C&L notifications submitted to ECHA

Acute Tox. 4 H302 Harmonised Classification
Resp. Sens. 1 H334 Harmonised Classification
Skin Corr. 1B H314 Harmonised Classification
Skin Sens. 1 H317
Eye Dam. 1 H318 Harmonised Classification
STOT RE 1 H372 Harmonised Classification
Skin Sens. 1A H317 Harmonised Classification
STOT RE 2 H373
Skin Sens. 1B H317
Acute Tox. 1 H330
Acute Tox. 3 H311
STOT SE 1 H370
STOT SE 2 H371
Skin Corr. 1A H314
Flam. Liq. 3 H226
https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).
  • Sr
Officially recognised in the EU as Respiratory sensitising ( Harmonised C&L).
  • Sr
There is broad agreement in that a majority of data submitters agree this substance is Respiratory sensitising (100% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 138 active registrations under REACH, 2 Joint Submission(s) and 3 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants, fertilisers, washing & cleaning products and water treatment chemicals.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: adhesives and sealants, fertilisers, pH regulators and water treatment products, laboratory chemicals, washing & cleaning products and water treatment chemicals.

This substance is used in the following areas: health services, agriculture, forestry and fishing and scientific research and development.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, laboratory work and open transfer and processing with minerals/metals at elevated temperature.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

This substance is used in the following products: polymers, water treatment chemicals, coating products, oil and gas exploration or production products, fertilisers, textile treatment products and dyes and washing & cleaning products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, mixing in open batch processes, closed, continuous processes with occasional controlled exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: polymers and laboratory chemicals. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: plastic products, rubber products and chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates) and for thermoplastic manufacture.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates) and for thermoplastic manufacture.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not breathe the dust, fume, gas, mist, vapours or spray; contaminated work clothing should not be allowed out of the workplace; do not eat, drink or smoke when using this product; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray; in case of inadequate ventilation wear respiratory protection.

Response statements

In case of incident: Wash contaminated clothing before reuse. If skin irritation or a rash occurs: get medical advice/attention. If inhaled: if breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If swallowed: rinse mouth. Do not induce vomiting. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If experiencing respiratory symptoms: call a poison center or doctor/physician. If swallowed: call a poison center or doctor/physician if you feel unwell.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • AAKO BV, Arnhemseweg 87 3832 GK Leusden Netherlands
  • AdvanSix Resins & Chemicals (Ireland) Limited, 13-18 City Quay D02 ED70 Dublin Ireland Ireland
  • AFCONA Additives B.V., Amperestraat 34 1704SN Heerhugowaard Netherlands
  • Afton Chemical S.P.R.L. (Woluwe), Alma Court Lenneke Marelaan, 8 B-1932 St-Stevens-Woluwe Belgium
  • ALBACHEM SRL, Via Timavo, 200 20099 Sesto San Giovanni Italy
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • ARKEMA FRANCE, 420 rue d'Estienne d'Orves 92700 COLOMBES France
  • ARLANXEO Netherlands B.V. (OR for Brazil), Urmonderbaan 24 6167 RD Geleen Netherlands
  • Ashland Services BV (0311), Noordweg 9 3336 LH Zwijndrecht Netherlands
  • Ashland Services BV (OR2), Noordweg 9 3336 LH Zwijndrecht Netherlands
  • BASF Performance Products France SA, 49, Avenue Georges Pompidou 92593 Levallois-Perret Cedex France
  • BASF Schwarzheide GmbH, Schipkauer Str. 1 01987 Schwarzheide Brandenburg Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BCS Only Representative Services Ltd, Pembroke House 30 Upper Pembroke Street Dublin 2 Dublin Ireland
  • Beiersdorf Customer Supply GmbH, Unnastrasse 48 20253 Hamburg Germany
  • BENS CONSULTING, kemijsko svetovanje, d.o.o., Bakovniška 7 SI1241 Kamnik Slovenia
  • BorsodChem Zrt. - OR, Bolyai ter 1. H-3700 Kazincbarcika Hungary
  • BSM-OR-polymers-Equistar, Delftseplein 27E 3013 AA Rotterdam Netherlands
  • C.S.B. GmbH, Düsseldorfer Strasse 113 47809 Krefeld Germany
  • Cargill B.V., Evert van de Beekstraat 378 1118 CZ Amsterdam Schiphol North Holland Netherlands
  • CCD (Germany) GmbH, Graf-Adolf-Strasse 68 40210 Düsseldorf Germany
  • CCI Manufacturing Germany GmbH, Borsigstr. 12 41541 Dormagen Germany
  • Celanese Europe BV, The New Atrium Strawinskylaan 3105 1077 ZX Amsterdam Netherlands
  • ChampionX Europe B.V., Oude Rhijnhofweg 17 NL-2342BB Oegstgeest Oegstgeest Netherlands
  • Charles River Laboratories Den Bosch B.V. OR69, Hambakenwetering 7 5231DD 's-Hertogenbosch Netherlands
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • Chemical Inspection & Regulation Service Limited, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre HW77 D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED (Shandong Taihe Water Treatment Technologies Co., Ltd.), Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemical Regulatory Services Limited, 27 Old Gloucester Street WC1N 3AX London United Kingdom
  • Cheminova A/S, Thyborønvej 76-78 DK-7673 Harboøre Denmark
  • Chevron Oronite SA - OR - CVX Japan Ltd, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Chevron Oronite SA - OR - CVX Oronite Cy LLC, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Chevron Oronite SA M/I, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Clariant Oil Services Scandinavia AS, PB 6054 5892 Bergen Norway
  • Clariant Oil Services UK Ltd, Howe Moss Place Kirkhill Industrial Estate AB21 0GS Dyce Aberdeen United Kingdom
  • Connect Chemicals Italia S.r.l., Via Torri Bianche, 9 20871 Vimercate (MB) Italy
  • ConvaTec Ltd, GDC First Avenue Deeside Industrial Park CH5 2NU Deeside Flintshire United Kingdom
  • Covance Clinical Development SA 172, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 - 5 Planta 28050 Madrid Spain
  • CRAY VALLEY SA OR8, 2 Place Jean Millier 92400 Courbevoie France
  • Dow Belgium B.V.B.A., Grotesteenweg 214 B-2600 Antwerpen (Berchem) Belgium Belgium
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-10, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW DEUTSCHLAND ANLAGENGESELLSCHAFT mbH, Am Kronberger Hang 4 D-65824 Schwalbach Germany
  • DOW ITALIA S.R.L., Via F. Albani 65 20148 Milano Italy
  • Eastman Chemical B.V., Watermanweg 70 3067 GG Rotterdam Netherlands
  • Elementis UK Ltd., Caroline House 55 - 57 High Holborn WC1V 6DX London United Kingdom
  • Enviresearch Portugal Unipessoal Limitada, Rua Fernando Pessoa, 319 2 C Sassoeiros 2775-515 Carcavelos Lisbon Portugal
  • ERM_GmbH_OR13_KM, Siemenstrasse 9. 63263 Neu Isenburg Hessen Germany
  • ESIM Chemicals GmbH, St.-Peter-Strasse 25 4020 Linz Austria
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • Evonik Performance Materials GmbH, Rellinghauser Strasse 1-11 45128 Essen Germany
  • Harke Services GmbH - OR1, Xantener Str.1 45479 Mülheim an der Ruhr Germany
  • Helm AG, Nordkanalstraße 28 20097 Hamburg Germany
  • Honeywell Belgium N.V., Interleuvenlaan 15i Haasrode Research Park B-3001 Heverlee Belgium
  • Honeywell Belgium NV OR-1000, Gaston Geenslaan 14 - 2nd Floor Arenberg Wetenschapspark B-3001 Heverlee Belgium
  • Huntsman (Europe) BV - OR1, Everslaan 45 B-3078 Everberg Belgium
  • Huntsman (Europe) BV - OR2, Everslaan 45 B-3078 Everberg Belgium
  • Huntsman Products GmbH, Roemerstr. 733 47443 Moers Germany
  • Huntsman Textile Effects (Germany) GmbH, Rehlinger Str. 1 D-86462 Langweid a.Lech Germany
  • Infineum Italia, Strada di Scorrimento 2 17047 Vado Ligure (SV) Italy
  • Infineum Italia, Strada di Scorrimento 2 17047 Vado Ligure (SV) Italy
  • Infineum Italia, Strada di Scorrimento 2 17047 Vado Ligure (SV) Italy
  • Innospec Limited (OR1), Innospec Manufacturing Park Oil Sites Road CH65 4EY Ellesmere Port Cheshire United Kingdom
  • Intertek Deutschland GmbH, Stangenstrasse 1 D-70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 16, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 6, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek deutschland GmbH TECH, Stangenstr. 1 70771 Leinfelden-Echterdingen Germany
  • Kao Chemicals Europe, S.L. (2), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Kemira Oyj, Energiakatu 4 P.O.Box 330 FI-00101 HELSINKI Finland
  • King Industries International, Science Park 402 1098 XH Amsterdam Amsterdam Netherlands
  • Kraton Chemical AB OR1, Massvagen 15 P.O. Box 66 SE-820 22 Sandarne Sweden
  • KTR Europe GmbH, Mergenthalerallee 77 65760 Eschborn Germany
  • Kuraray Europe GmbH (OR1), Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Lanxess Corp OR, Chempark 51369 Leverkusen NRW Germany
  • Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany
  • Lawter BVBA, Haven 1520 Ketenislaan 1 B-9130 Kallo East Flanders Belgium
  • Lubrizol Deutschland GmbH, Max-Planck-Strasse 6 27721 RITTERHUDE Germany
  • Lubrizol Europe Coordination Center BVBA 01, Chaussee De Wavre, 1945 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 02 , Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 05, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 06, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 07, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 09, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 12, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 16, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • Lubrizol Limited, The Knowle, Nether Lane Hazelwwod DE56 4AN Derby Derbyshire United Kingdom
  • Lubrizol Limited 16, The Knowle,Nether Lane DE56 4AN Derby Derbyshire United Kingdom
  • MHM Holding GmbH, Feldkirchener Straße 15 D-85551 Kirchheim Germany
  • Michelman International Belgium SRL OR, Zoning Industriel B-6790 Aubange Belgium
  • MOEHS CANTABRA, P.I.Requejada Z-23 39313 Polanco Cantabria Spain
  • MOL Hungarian Oil and Gas Public Limited Company, Oktober huszonharmadika 18 1117 Budapest Hungary
  • Nalco Limited, P.O. Box 11, Winnington Avenue, CW8 4DX Northwich, Cheshire United Kingdom
  • Nippon Gohsei UK Ltd, Soarnol House Saltend HU12 8DS Hull East Yorkshire United Kingdom
  • Nouryon Chemicals NV/SA, Parc Industriel de Ghlin Zone A 7011 Ghlin Mons Belgium
  • Nouryon Functional Chemicals B.V., Velperweg 76 6824 BM Arnhem Netherlands
  • Nouryon Surface Chemistry AB, Stenunge Allé 3 - S-44485 Stenungsund - Sweden
  • NuCera Solutions France SARL, Tour Ariane, 10th floor 5 place de la Pyramide F-92088 Paris La Defense France
  • Penpet Petrochemical Trading GmbH, Merkurring 105 22143 Hamburg Germany
  • Performance Materials Ibérica, S.L.U., Jose Abascal 56 28003 Madrid Spain
  • Performance Specialty Products Ibérica, S.L.U., Valle de Tamón - Nubledo 33469 Tamón - Carreño Asturias Spain
  • POLYNT S.p.A., via Enrico Fermi, 51 I-24020 Scanzorosciate BG Italy
  • POLYNT S.p.A. OR1, via Enrico Fermi, 51 I-24020 Scanzorosciate BG Italy
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Industries Italia Srl Società soggetta a direzione e coordinamento da parte di PPG Industries Inc., Via Serra, 1 15028 Quattordio Italy
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • RHODIA OPERATIONS - 17, 40 rue de la Haie Coq 93306 Aubervilliers France
  • RHODIA OPERATIONS - 2, 40 rue de la Haie Coq 93306 Aubervilliers France
  • Roehm America LLC - ORR1, Deutsche-Telekom-Allee 9 64295 Darmstadt Germany
  • Ruse Chemicals, 133, Bulgaria blvd. 7000 Rousse Bulgaria
  • Röhm GmbH, Deutsche-Telekom-Allee 9 64295 Darmstadt Germany
  • SI Group DEAB (Imp), Teplitzer Strasse 84478 Waldkraiburg Germany
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • SNF SA, ZAC de Milieux 42163 Andrézieux France
  • Solenis Netherlands B.V., Fascinatio Boulevard 522 2909 VA CAPELLE A/D IJSSEL Netherlands
  • SOLVAY SOLUTIONS NEDERLAND B.V., ENERGIEWEG 1 4791RN Klundert Netherlands
  • SP Automotive GmbH, Viktoriastr. 32-36 56068 Koblenz Germany
  • Stafford-Miller (Ireland) Limited, Clocherane Youghal Road _ Dungarvan Waterford Ireland
  • STEPAN EUROPE SA, Chemin JONGKIND 38340 VOREPPE France
  • Stewardship Chemicals 28, Green Lowe Farm, Shawclough Road Waterfoot BB4 9SA Rossendale Lancashire United Kingdom
  • SUEZ Water Technologies & Solutions Belgium BVBA, Toekomstlaan 54 2200 Herentals Belgium
  • SUEZ WTS France, Tour CB21 16 Place de l’Iris 92040 Paris La Défense France
  • TCL GLOBAL BV as ONLY REPRESENTATIVE OF OOSB, Saturnusstraat 46-62 2132 HB Hoofddorp Netherlands
  • TramacoGmbH, Lise-Meitner-Allee 8 25411 Tornesch Germany
  • TÜV SÜD Iberia S.A.U. (003), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Iberia S.A.U. (051), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • Vertellus Specialties UK Ltd, Seal Sands Road Seal Sands TS2 1UB Middlesbrough Cleveland United Kingdom
  • Wacker Chemie AG, Hanns-Seidel-Platz 4 81737 Muenchen Germany
  • WEGeuro - Indústria Eléctrica, S.A., Rua Engº Frederico Ulrich, Zona industrial da Maia sector V 4470-605 Maia Porto Portugal
  • [Confidential], [Confidential]
  • Chemours Netherlands B.V., Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • COMPANÍA ESPAÑOLA DE PETRÓLEOS, S.A.U. (CEPSA), Torre Cepsa, Paseo de la Castellana 259A 28046 Madrid Spain
  • Grupa Azoty Zakłady Azotowe Kędzierzyn Spółka Akcyjna, skr. poczt. 163 ul. Mostowa 30A 47-220 Kędzierzyn-Kożle Poland
  • Huntsman (Europe) BV - OR4, Everslaan 45 B-3078 Everberg Belgium
  • Intertek Deutschland GmbH, Stangenstrasse 1 D-70771 Leinfelden-Echterdingen Germany

Substance names and other identifiers

2,5-Furandione
Other
Anhydrid kyseliny maleinove
Other
cis-Butenedioic anhydride
Other
Dihydro-2,5-dioxofuran
Other
Maleic acid anhydride
Other
Maleic anhydride
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, REACH pre-registration, Other, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
MALEIC ANHYDRIDE, MOLTEN
Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID
Toxilic anhydride
Other
anhidrid maleinske kiseline (hr)
C&L Inventory
anhidrid maleinske kisline (sl)
C&L Inventory
anhidrida maleica (ro)
C&L Inventory
anhydride maléique (fr)
C&L Inventory
anhídrido maleico (es)
C&L Inventory
anidride maleica (it)
C&L Inventory
anidrido maleico (pt)
C&L Inventory
bezwodnik maleinowy (pl)
C&L Inventory
Maleiinanhüdriid (et)
C&L Inventory
maleiinianhydridi (fi)
C&L Inventory
maleinanhydrid (cs)
C&L Inventory
maleinezuuranhydride (nl)
C&L Inventory
maleino rūgšties anhidridas (lt)
C&L Inventory
maleinsav-anhidrid (hu)
C&L Inventory
maleinsyraanhydrid (sv)
C&L Inventory
maleinsyreanhydrid (da)
C&L Inventory
Maleinsäureanhydrid (de)
C&L Inventory
maleínanhydrid (sk)
C&L Inventory
maleīnanhidrīds (lv)
C&L Inventory
μηλεϊνικός ανυδρίτης (el)
C&L Inventory
анхидрид на малеиновата киселина (bg)
C&L Inventory
2,5-dihydrofuran-2,5-dione
C&L Inventory, Registration dossier, Other
butenedioic anhydride, toxilic anhydride, 2,5-dioxofuran
C&L Inventory
fruan-2,5-dione
Registration dossier
Furan - 2,5 - dione
C&L Inventory
furan-2,5-dion
C&L Inventory
Furan-2,5-dione
C&L Inventory, Registration dossier, Other
Furan-2.5-dione
C&L Inventory
Furane-2,5-dione
C&L Inventory
Maleic Abhydride
C&L Inventory
2,5 Furandione
Registration dossier
2,5-Diossi-diidrofurano
Registration dossier
2,5-Dioxo-dihydrofuran
Registration dossier
2,5-Furandion
Registration dossier
2,5-Furandion, MSA, cis-Butensäureanhydrid
Registration dossier
2,5-Furandione (9CI)
Registration dossier
2,5-Furandione (9Cl)
Registration dossier
2,5-Furandione, Maleinsäureanhydrid
Registration dossier
2,5-Furanedione
Registration dossier
2,5-FURANEDIONE. TOXILIC ANHYDRIDE.CIS-BUTENEDIOIC ANHYDRIDE
Registration dossier
2-5 Furandiona
Registration dossier
2-Butendicarbonsaeureanhydrid
Registration dossier
2.5 furandion
Registration dossier
Anhydride maleique; cis-butenedioic anhydride
Registration dossier
Anidride Cis-Butendioica
Registration dossier
Anidride dell'acido cis-etilendicarbossilico
Registration dossier
Anidride dell'acido maleico
Registration dossier
Anidride maleica solida
C&L Inventory
Anidride tossilica
Registration dossier
Aropol
Registration dossier
BM 10
Registration dossier
cis- Ethendicarboxylic Anhydride
Registration dossier
cis-Butanedioic anhydride
Registration dossier
cis-butendioc anhydride
Registration dossier
cis-Butenedioic anhydrides Maleic anhydride
Registration dossier
cis-Butensäureanhydrid
Registration dossier
cis-Butensäureanhydrid, MSA
Registration dossier
cis-Ethendicarbonsaeureanhydrid
Registration dossier
Crystal Man
Registration dossier
EPS
Registration dossier
Ethylendicarbonsaeureanhydrid
Registration dossier
furandione
Registration dossier
MA
Registration dossier
Maleic acid anhydride, cis-Butenedioic anhydride.
Registration dossier
Maleic anhydride (8CI)
Registration dossier
maleic anhydride (8Cl)
Registration dossier
Maleic anhydride; cis-butenedioc anhydride; maleic acid anhydride
Registration dossier
Maleicanhydride
Registration dossier
Maleinsaeureanhydrid
Registration dossier
Maleinsavanhidrid
Registration dossier
MAN
Registration dossier
Maxguard
Registration dossier
MSA
Registration dossier
Nourymix MA 901
Registration dossier
Optipak 200
Registration dossier
Polybond 2006
Registration dossier
Polybond 2021
Registration dossier
Polybond 2021P
Registration dossier
Polybond 3001
Registration dossier
Polybond 3002
Registration dossier
Polybond 3005
Registration dossier
Polybond 3009
Registration dossier
108-31-6
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, FCM and Articles Regulation, Annex I - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
1190407-73-8
CAS number
Other
1229972-04-6
CAS number
Other
1380217-40-2
CAS number
Other
184288-31-1
CAS number
Other
607-096-00-9
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [2]
C Form
Other (100%) [2]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)
Form
Solid (100%)
Colour
white (100%)
Colour Intensity
light (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 2 studies processed
R Melting / freezing point
51.2 - 58 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
53 - 55 °C

Boiling point

Study results
  • 5 studies submitted
  • 2 studies processed
R Boiling point
185 - 200.1 °C @ 101 - 101.37 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
200 - 200.1 °C

Density

Study results
  • 5 studies submitted
  • 3 studies processed
R Density
1.3 - 1.48 g/cm³ @ 20 - 60 °C [2]
R Relative density
1.48 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Relative density at 20°C
1.48 - 1 480

Vapour pressure

Study results
  • 6 studies submitted
  • 2 studies processed
R Vapour pressure
15.1 - 108 Pa @ 22 - 40 °C [6]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 2 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
15.1 - 21.332 Pa @ 20 - 22 °C

Partition coefficient

Study results
  • 4 studies submitted
  • 2 studies processed
R Log Pow
-2.78 - -2.36 @ 19.8 °C and pH 4 - 9 [4]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
-2.61 @ 20 °C

Water solubility

Study results
  • 3 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
402 - 418 g/L @ 20 °C and pH 4 - 9 [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
407 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Flash point at 101 325 Pa
103.333 °C

Auto flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 3 studies submitted
  • 2 studies processed
C Interpretation of results
Not classified based on GHS criteria (50%), Non flammable (50%) [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other 1
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 2 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
0 - 0.011 @ 25 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
0

Viscosity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 5 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
8.5 h [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 3 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
18 s @ 25.1 °C

Phototransformation in water

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 11 studies submitted
  • 2 studies processed
C Interpretation of results
Readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 4 1
Weight of evidence
Other 3
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Readily biodegradable (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 5 studies submitted
  • 1 study processed
R Koc
42 dimensionless [1]
R log Koc
1.63 dimensionless [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
42

Henrys law constant (H)

Study results
  • 3 studies submitted
  • 1 study processed
R H - (pressure) m³/mol
0 Pa m³/mol @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 2 studies submitted
  • 1 study processed
% Distribution in Media:
R Air 0 % [1]
R Water 100 % [1]
R Soil 0 % [1]
R Sediment 0 % [1]
R Suspended sediment 0 % [1]
R Biota 0 % [1]
R Aerosol 0 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 37.9 - 75 µg/L (2)
Intermittent releases (freshwater) 379 - 750 µg/L (2)
Marine water 3.79 - 7.5 µg/L (2)
Intermittent releases (marine water) 37.9 µg/L (1)
Sewage treatment plant (STP) 4.46 - 44.6 mg/L (2)
Sediment (freshwater) 60 - 296 µg/kg sediment dw (2)
Sediment (marine water) 6 - 29.6 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 10 - 36.9 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning 6.67 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 17 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 75 mg/L [2]
LC50 (48 h) 75 mg/L [2]
LC50 (24 h) 75 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence 2
Other 11 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
75 mg/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 9 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 42.81 - 330 mg/L [2]
EC50 (24 h) 340 mg/L [1]
NOEC (48 h) 17.5 mg/L [1]
LOEC (48 h) 30.63 mg/L [1]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 3 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 / LC50 for freshwater invertebrates
37.9 - 330 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 7 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 74.35 - 150 mg/L [3]
NOEC (72 h) 150 mg/L [2]
EC10 (72 h) 11.8 mg/L [1]
EC20 (72 h) 22.2 mg/L [1]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 1
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
65.78 - 150 mg/L
EC10 or NOEC for freshwater algae
10.4 - 150 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 12 studies submitted
  • 2 studies processed
P/RResults
EC50 (15 min) 12.5 mg/L [1]
EC10 (18 h) 44.6 mg/L [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 7 1
Other 4
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 or NOEC for microorganisms
44.6 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 81 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 200 µg/m³ irritation (respiratory tract)
Local Effects
Long-term: (DNEL) 81 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 200 µg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 200 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 200 µg/kg bw/day repeated dose toxicity
Local Effects
Long-term: (High hazard (no threshold derived)) -
Acute /short term: (High hazard (no threshold derived)) -
EYE Exposure
High hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 50 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 80 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 100 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 100 µg/kg bw/day repeated dose toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 60 µg/kg bw/day effect on fertility
Acute /short term: (DNEL) 100 µg/kg bw/day repeated dose toxicity
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 11 studies submitted
  • 1 study processed
P/RResults
LD50 1 090 mg/kg bw (rat) [1]
M/CInterpretations of results
Category 4 based on GHS criteria [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 8
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
inhalation
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
dermal
  • 6 studies submitted
  • 1 study processed
P/RResults
LD50 2 620 mg/kg bw (rabbit) [1]
M/CInterpretations of results
GHS criteria not met [1]

dermal
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 1 090 mg/kg bw
Dermal route:
Adverse effect observed LD50 2 620 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
Adverse effect observed (corrosive)
Eye
Adverse effect observed (irreversible damage)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: respiratory
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
Adverse effect observed (sensitising)
Respiratory sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 10 studies submitted
  • 5 studies processed
P/RResults
NOAEL (rat): 10 - 250 mg/kg bw/day [2]
NOAEL (dog): 60 mg/kg bw/day [1]
LOAEL (rat): 100 - 600 mg/kg bw/day [2]
NOEL (rat): 10 - 40 mg/kg bw/day [2]
LOEL (rat): 32 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 3 1
Weight of evidence 4
Other 1
Data waiving
no waivers
Study data: inhalation
  • 8 studies submitted
  • 7 studies processed
P/RResults
NOAEC (rat): 3.3 mg/m³ air [2]
NOAEC (hamster): 9.8 mg/m³ air [2]
NOAEC (monkey): 9.8 mg/m³ air [2]
LOAEC (rat): 1.1 - 10 mg/m³ air [4]
LOAEC (hamster): 1.1 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 3
Supporting study 1
Weight of evidence 4
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
No adverse effect observed NOAEL 60 mg/kg bw/day (subchronic, dog)
Inhalation route - systemic effects:
Adverse effect observed NOAEC 3.3 mg/m³ (subchronic, rat)
Inhalation route - local effects:
Adverse effect observed LOAEC 1.1 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study
Supporting study 4
Weight of evidence 6 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study 1
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 100 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 55 mg/kg bw/day (chronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 140 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant