Registration Dossier
Registration Dossier
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EC number: 204-857-3 | CAS number: 127-68-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- Data is from experimental study report.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- A Draize Test was carried out for chemical Sodium 3-nitrobenzenesulphonate (CAS no: 127-68-4) to assess its skin irritation potential.
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium 3-nitrobenzenesulphonate
- EC Number:
- 204-857-3
- EC Name:
- Sodium 3-nitrobenzenesulphonate
- Cas Number:
- 127-68-4
- Molecular formula:
- C6H5NO5S.Na
- IUPAC Name:
- sodium 3-nitrobenzenesulphonate
- Test material form:
- solid
- Details on test material:
- Name of the test chemical: Sodium 3-nitrobenzenesulfonate
Molecular Formula:C6H5NO5S.Na
Molecular Weight: 225.1556 g/mol
Substance Type: Organic
Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical: Sodium 3-nitrobenzenesulfonate
Molecular Formula:C6H5NO5S.Na
Molecular Weight: 225.1556 g/mol
Substance Type: Organic
Physical State: Solid
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- Mean body weights for male animals 2.87 kg, female animals 2.97 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: either intact or abraded
- Vehicle:
- water
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- Concentration: 50%
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 8 d
- Number of animals:
- 6
- Details on study design:
- After the application time, the skin was washed with water which may have contained a mild detergent. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 24, 72 hours and at the end of the observation period. Findings were graded as described in OECD test guideline 404.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 1.2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 1.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 d
- Remarks on result:
- other: intact skin
- Irritant / corrosive response data:
- All skin reactions were disappeared within 8 days.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- From the experimental results, it is concluded that Sodium 3-nitrobenzenesulphonate (CAS no: 127-68-4)was not irritating to the skin of white Vienna rabbits.
- Executive summary:
A Draize Test was carried out for chemical Sodium 3-nitrobenzenesulphonate (CAS no: 127-68-4) on skin of six white Vienna rabbits in accordance with OECD test guideline 404.
The chemical was applied to the intact or abraded skin of each rabbit at a dose of 50% of Sodium 3-nitrobenzenesulphonate in water for 24 hours under occlusive condition.
After the application time, the skin was washed with water which may have contained a mild detergent. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 24, 72 hours and at the end of the observation period. Findings were graded as described in OECD test guideline 404.
The chemical caused slight erythema and edema which were fully reversible within 8 days.
Since the observed effects were not persisted during the observed period, the chemical Sodium 3-nitrobenzenesulphonate (CAS no: 127-68-4) was considered as not irritating to the skin of white Vienna rabbits.
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