Registration Dossier
Registration Dossier
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EC number: 200-835-2 | CAS number: 75-05-8
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original report in German was not fully translated. Only summary results are presented.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
- Principles of method if other than guideline:
- Repeated application of acetonitrile to rabbit ears.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Acetonitrile
- EC Number:
- 200-835-2
- EC Name:
- Acetonitrile
- Cas Number:
- 75-05-8
- Molecular formula:
- C2H3N
- IUPAC Name:
- acetonitrile
- Details on test material:
- - Name of test material (as cited in study report): Acetonitrile
- Analytical purity: 99.5% according to manufacturer
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Acetonitrile
- Analytical purity: 99.5% according to manufacturer
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Details on exposure:
- Repeated application to both ears.
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 24 hrs for each treatment
- Frequency of treatment:
- 4 treatments over ten days.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
4 ml (2 ml on each ear)
Basis:
- No. of animals per sex per dose:
- 3 rabbits
Results and discussion
Effect levels
- Basis for effect level:
- other: light purple skin discoloration but no symptoms of systemic poisoning
- Remarks on result:
- not measured/tested
- Remarks:
- Effect level not specified (migrated information)
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The repeated application of 4 ml acetonitrile per animal on both ears resulted in light purple skin discoloration. Systemic poisoning symptoms were not observed. Investigation of the urine revealed no pathological findings. Body weights decreased during the study period, but recovered during a three week follow-up period.
Applicant's summary and conclusion
- Executive summary:
BASF (1960) reported light purple skin discoloration but no symptoms of systemic poisoning following repeated (4 treatments) application of acetonitrile to the ears of rabbits.
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