Registration Dossier
Registration Dossier
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EC number: 402-130-7 | CAS number: 106246-33-7
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: 67/548/EEC, Annex V, A.7
- Deviations:
- no
- GLP compliance:
- yes
- Key result
- Medium:
- standard fat
- Remarks:
- HB 307 Natec
- Solubility:
- 17 000 mg/100 g solvent
- Temp.:
- 37 °C
- Test substance stable:
- yes
- Conclusions:
- The solubility of the test item in standard fat was determined to be 170 g/kg standard fat (corresponds to 136.56 g/l) . Temperature of measurement was 37.0 - 37.3°C.
- Executive summary:
The study was performed 1987 as GLP-test following EU-testing method A.7 using the flask shaking method. The solubility of the test item in standard fat was determined to be 170 g/kg standard fat (corresponds to 136.56 g/l). Temperature of measurement was 37.0 - 37.3°C. A separate study conducted by another lab gave a result of 16500 mg/100 g of HB307.
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: 67/548/EEC, Annex V, A.7
- Deviations:
- no
- GLP compliance:
- yes
- Key result
- Medium:
- standard fat
- Remarks:
- HB 307 Natec
- Solubility:
- 16 500 mg/100 g solvent
- Temp.:
- 37 °C
- Test substance stable:
- yes
- Conclusions:
- The solubility of the test item in standard fat was determined to be 165 g/kg standard fat HB 307 NATEC. Temperature of measurement was 37.0°C.
- Executive summary:
The study was performed 1987 as GLP-test following EU-testing method A.7 using the flask shaking method. The solubility of the test item in standard fat was determined to be 165 g/kg standard fat (corresponds to 132.5 g/l). Temperature of measurement was 37.0°C.
Referenceopen allclose all
Description of key information
The fat solubility was measured at two different test laboratories. In both labs, the studies were both performed under GLP and in accordance with EU-testing method A.7, showing almost similar results. The value of 17000 mg/L (37°C) of the key study was used for the safety assessment.
Key value for chemical safety assessment
- Solubility in mg/100g standard fat:
- 17 000
- At the temperature of:
- 20 °C
Additional information
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