Registration Dossier
Registration Dossier
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EC number: 231-977-3 | CAS number: 7783-06-4
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract quoted in a peer review from US EPA.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- TOXICOLOGICAL REVIEW OF HYDROGEN SULFIDE (CAS No. 7783-06-4). In Support of Summary Information on the Integrated Risk Information System (IRIS)
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 003
- Bibliographic source:
- EPA/635/R-03/005. www.epa.gov/iris
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
- Principles of method if other than guideline:
- Assessment of the effect of H2S on spermatogenesis
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- Hydrogen sulphide
- EC Number:
- 231-977-3
- EC Name:
- Hydrogen sulphide
- Cas Number:
- 7783-06-4
- Molecular formula:
- H2S
- IUPAC Name:
- hydrogen sulfide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: gas
- Duration of treatment / exposure:
- 7 days
- Frequency of treatment:
- 3 hr/day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
220 ppm (306 mg/m3)
Basis:
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- Following the last exposure, each male was caged with two unexposed virgin females for 10 consecutive weeks. Four male rats were administered triethylenemelamine and used as positive controls. The females were sacrificed after 18 days cohabitation. Parameters evaluated included fertility, corpora lutea, total implants, and dead implants.
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- >= 220 ppm
- Sex:
- male
Observed effects
Applicant's summary and conclusion
- Executive summary:
The effect of H2S on spermatogenesis in the rat was assessed by Andrew et al. (1980). A group of 10 14-week-old male Wistar rats were exposed to 220 ppm (306 mg/m3) H2S for 3 hr/day for 7 days, compared to a control or nonexposed group. Following the last exposure, each male was caged with two unexposed virgin females for 10 consecutive weeks. Four male rats were administered triethylenemelamine and used as positive controls. The females were sacrificed after 18 days cohabitation. Parameters evaluated included fertility, corpora lutea, total implants, and dead implants. There were no adverse effects of exposure on these parameters.
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