Registration Dossier
Registration Dossier
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EC number: 225-464-3 | CAS number: 4861-19-2
Endpoint summary
Administrative data
Description of key information
Urea phosphate is dissociated into urea and phosphoric acid. Phosphoric acid shows a lower toxicity level in oral toxicity, while no dermal and inhalation studies are available and thus not required because the substance is classified as skin corrosive.
Acute toxicity: oral - An oral LD50 of 1.70 mL/100 g body weight in SPF-Wister K rats for a 10% solution of 75.4% thermal phosphoric acid was observed.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 600 mg/kg bw
Additional information
Urea phosphate will directly dissociate into urea and phosphoric acid in an aqueous environment.
Acute toxicity: oral
An LD50 of 1.70 ml/100 g body weight in SPF-Wister K rats for a 10% solution of 75.4% thermal phosphoric acid (study performed according to OECD Guideline 423) was observed. This is approximately 2600 mg/kg bw.
Urea is of very low acute oral toxicity in the rat with an LD50 of 14300 mg/kg bw.
Acute toxicity: inhalation No reliable data are available for phosphoric acid and urea. Urea phosphate has a low vapour pressure and a high particle size, resulting in negligible inhalation exposure possible. In addition, urea phosphate is classified as corrosive to skin and thus no study is required. Acute dermal toxicity Phosphoric acid is classified as corrosive to the skin. There is no concern for the dermal route of exposure as personal protective equipment is used (gloves and googles) in the production and use of phosphoric acid. In addition key studies are available for acute oral toxicity and acute inhalation toxicity. Therefore, there is no need to perform an acute dermal toxicity test.Justification for classification or non-classification
Based on the available data urea phosphate should not be classifed according to Directive 67/548/EC and the CLP Regulation (EC) No 1272/2008 for this endpoint.
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