Registration Dossier
Registration Dossier
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EC number: 205-517-7 | CAS number: 141-98-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 AUG 2012 - 13 SEP 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 301 D
- Deviations:
- no
- Principles of method if other than guideline:
- In biodegradation test OECD 301 D the oxygen consumption corresponded to 35.4% of the ThOD after 14 days in the toxicity control. Therefore, the test item can be considered not inhibitory to the inoculum according to this test guideline
- GLP compliance:
- yes
- Test organisms (species):
- sewage, domestic
- Details on inoculum:
- secondary effluent from a municipal wastewater treatment plant in Usserød, Denmark, wihich predominantly receives domestic sewage
- Total exposure duration:
- 28 d
- pH:
- Start of test: 7.3 - 7.5
End of test: 7.1 - 7.5 - Dissolved oxygen:
- Start of test: 9.06 - 9.12
End og test: 5.99 - 6.22 - Reference substance (positive control):
- yes
- Remarks:
- Sodium benzoate
- Key result
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.2 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- inhibition of total respiration
- Key result
- Duration:
- 28 d
- Dose descriptor:
- other: Oxygen consumption
- Effect conc.:
- 35.1 other: % of ThOD
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- other: oxygen elektrode
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Validity criteria fulfilled:
- yes
- Conclusions:
- The oxygen consumption corresponded to 35.4% of the ThOD after 14 days in the toxicity control. Therefore, the test item can be considered not inhibitory to the inoculum according to this test guideline.
- Executive summary:
Biodegradation test was done according to OECD Guideline 301D. The oxygen consumption corresponded to 35.4% of the ThOD after 14 days in the toxicity control. Therefore, the test item can be considered not inhibitory to the inoculum according to this test guideline.
Reference
Description of key information
OECD 301D; oxygen consumption 35.4% of the ThOD 14 days ;not inhibitory to the inoculum, NOEC 2.2 mg/L
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 2.2 mg/L
Additional information
Biodegradation test was done according to OECD Guideline 301D. The oxygen consumption corresponded to 35.4% of the ThOD after 14 days in the toxicity control. Therefore, the test item can be considered not inhibitory to the inoculum according to this test guideline.
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