Registration Dossier
Registration Dossier
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EC number: 238-969-9 | CAS number: 14901-07-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative data base
- Title:
- GCID : 93884
- Author:
- MORTELMANS,K, HAWORTH,S, LAWLOR,T, SPECK,W, TAINER,B AND ZEIGER,E
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource);MORTELMANS,K, HAWORTH,S, LAWLOR,T, SPECK,W, TAINER,B AND ZEIGER,E; SALMONELLA MUTAGENICITY TESTS: II. RESULTS FROM THE TESTING OF 270 CHEMICALS; ENVIRON. MUTAGEN. 8(SUPPL. 7):1 -119, 1986
- Reference Type:
- other: QSAR toolbox
- Title:
- QSAR study for 14901-07-6
- Author:
- QSAR toolbox
- Year:
- 2 011
- Bibliographic source:
- OECD QSAR toolbox version 2.2, 2011; P&G Inventory
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from ACToR database
- GLP compliance:
- not specified
- Type of assay:
- bacterial gene mutation assay
Test material
- Reference substance name:
- 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one
- EC Number:
- 238-969-9
- EC Name:
- 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one
- Cas Number:
- 14901-07-6
- Molecular formula:
- C13H20O
- IUPAC Name:
- 4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one
- Details on test material:
- -Name of test material (as cited in study report): 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one
- Substance type: Organic
- Physical state: liquid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 100
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with
- Metabolic activation system:
- HAMSTER, LIVER, S-9, AROCLOR 1254 (10%)
- Test concentrations with justification for top dose:
- 3.3-180 UG/PLATE
- Details on test system and experimental conditions:
- Test condition: PREINCUBATION
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Genetic toxicity with Metabolic Activation of HAMSTER, LIVER, S-9, AROCLOR 1254 (10%) by bacterial gene mutation assay to TA98 AMES SALMONELLA TYPHIMURIUM was examined to be NEGATIVE. - Executive summary:
Genetic toxicity with Metabolic Activation of HAMSTER, LIVER, S-9, AROCLOR 1254 (10%) by bacterial gene mutation assay to TA98 AMES SALMONELLA TYPHIMURIUM was examined to be NEGATIVE.
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