Registration Dossier
Registration Dossier
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EC number: 267-029-0 | CAS number: 67762-64-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance is considered to have a low bioaccumulation potential.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
By read-across, there is no evidence that heptanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol pentanoate is significantly absorbed via the dermal route. The results of an oral repeated dose toxicity studies with read-across substance, fatty acids, C5-10, esters with pentaerythritol, indicate that heptanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3 -propanediol pentanoate may be absorbed orally. It is likely that the ester groups in heptanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol pentanoate undergo lipase-catalysed hydrolysis in the gastrointestinal tract, releasing short chain fatty acids and trimethylolpropane. Following absorption, the short chain fatty acids are transported to the tissues of the body including the liver where they undergo oxidation in the cells. Trimethylolpropane is water soluble therefore it is most probably excreted in the urine unchanged or in conjugated form.
In conclusion, the substance has low bioaccumulation potential. A default absorption rate of 100% for the oral, inhalation and dermal routes is proposed to be taken for risk characterisation purposes as a worst case.
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