Registration Dossier
Registration Dossier
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EC number: 267-029-0 | CAS number: 67762-64-5
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A 15-day reproduction test with read-across substance, decanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol octanoate, showed no effects in the range of water solubility with an NOELR = 2570 mg/L (15 d) based on reproduction and immobilisation. Therefore, by read-across, heptanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol pentanoate is not expected to cause long-term toxicity in aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2 570 mg/L
Additional information
A 15-day reproduction test with read-across substance, decanoic acid, ester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol octanoate, showed no effectsin the range of water solubility with an NOELR = 2570 mg/L (15 d) based on reproduction and immobilisation. The study period of 15 days does not meet the criteria of current recommendations regarding a 21 day study duration. However the validity criteria stated in ECHA Guidance on information requirements and chemical safety assessment, Chapter R.7b were fulfilled (e.g. 80% survival in the control, surviving females produce three broods in 21 days or less, > 60 brood neonates per female in the control on average). Thus all requested endpoints could be determined (time to first brood, number of offspring produced per female, growth and survival) and NOELR values for survival or reproductive endpoints could be calculated. In accordance with ECHA Guidance on information requirements and chemical safety assessment, Chapter R.7b the study is considered as valid.
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