Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 295-653-3 | CAS number: 92113-48-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EL10 (16 h): > 10000 mg/L for growth inhibition of Pseudomonas putida (ISO 10712), read across
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity towards microorganisms of fatty acids, C14-18 and C16-18-unsatd., mixed esters with castor oil, castor oil Fatty acids, 2-ethylhexanoic acid and 2,2-bis(hydroxymethyl)-1-butanol (CAS No. 92113-48-9) are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally similar analogue substance Fatty acids, C14 -18 and C18 -unsatd., branched and linear, esters with trimethylolpropane (CAS No. 85005-23-8) was conducted. This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the analogue justification in IUCLID Section 13. The read across is justified based on common breakdown products, similar physico-chemical properties, environmental fate, toxicological and ecotoxicological properties.
The cell multiplication inhibition test with the read-across substance Fatty acids, C14 -18 and C18 -unsatd., branched and linear, esters with trimethylolpropane (CAS No. 85005-23-8) was performed according to ISO 10712 and resulted in an EL10 and EL50 (16 h) > 10000 mg/L (Pateman, 1997). No effects on growth of Pseudomonas putida was observed at a WAF loading rate of 10000 mg/L (clearly above the water solubility of read across and target substance (< 1 mg/L)). Thus, a disturbance in the biodegradation process of sewage treatment plant is not anticipated.
In addition, the test item can assumed to be not inhibitory on activated sludge microorganisms, since degradation of 56% within 14 days were observed in the toxicity control of an OECD 301F test (see chapter 5.2.1 of this technical dossier).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
