2-methylbut-3-en-2-ol

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standard methods

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1972

Report date:

1972

Materials and methods

Principles of method if other than guideline:

Internal BASF method was used

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methylbut-3-en-2-ol

EC Number:

204-068-4

EC Name:

2-methylbut-3-en-2-ol

Cas Number:

115-18-4

Molecular formula:

C5H10O

IUPAC Name:

2-methylbut-3-en-2-ol

Details on test material:

- Name of test material (as cited in study report): 2-methylbut-3-en-2-ol
- Analytical purity: 98.5-99%
- Physical state: clear liquid

Test animals

Species:

mouse

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Kisslegg
- Weight at study initiation: mean 33.2 g (males), 26.4 g (females)

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

other: 20 % aqueous emulsion

Doses:

640, 800, 1000, 1250, 1600, 2000, 2500 and 3200 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing prior to begin of study; observations were made daily
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 1 000 mg/kg bw

Mortality:

3200 mg/kg bw: 5/5 males and 5/5 females within 24 h
2500 mg/kg bw: 5/5 males and 5/5 females within 24 h
2000 mg/kg bw: 4/5 males and 5/5 females within 24 h
1600 mg/kg bw: 1/5 males within 24 h; 5/5 males and 5/5 females within 7 days
1250 mg/kg bw: 5/5 males and 3/5 females within 7 days
1000 mg/kg bw: 1/5 females within 24 h; 4/5 females within 7 days, 5/5 females within 14 days
800 mg/kg bw: 1/5 males within 7 days
640 mg/kg bw: 1/5 males within 24 h

Clinical signs:

- Immediately after injection and at the following observation days the animals showed disturbance of equilibrium, dyspnoea, cyanosis, abdominal and lateral position;
- after 90 min: apathy, shallow respiration, staggering, reddened eyes, squatting posture and poorly general condition.
- After 11 days the surviving animals showed no symptoms

Gross pathology:

- Most animals showed livers of yellow loam colour (degeneration); sporadic observations: general congestion, slightly agglutination from liver and stomach, distinctive appearance of liver lobules.