Potassium perrhenate

Eye irritation

Administrative data

Endpoint:

eye irritation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

Not given

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Published paper with little experimental detail. But data appears to be scientifically acceptable.

Data source

Reference

Reference Type:

publication

Title:

Pharmacology and toxicology of potassium perrhenate and rhenium trichloride

Author:

Haley T.J. and Cartwright F.D.

Year:

1968

Bibliographic source:

Journal of Pharmaceutical Sciences Vol 57 (No. 2), 321-323

Materials and methods

Test guideline

Qualifier:

no guideline followed

Guideline:

other: Draize J.H. et al. (1944). J. Pharmacol. Exptl. Therap. 82, 377

Principles of method if other than guideline:

The method of Draize et al. (1944) was used to study eye irritation in rabbits. 3 mg of material applied to one eye in each of two rabbits and assessed for irritation.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Potassium perrhenate

EC Number:

233-953-8

EC Name:

Potassium perrhenate

Cas Number:

10466-65-6

Molecular formula:

K.O4Re

IUPAC Name:

Potassium oxido(trioxo)rhenium

Test material form:

solid: crystalline

Details on test material:

- Name of test material (as cited in study report): Potassium perrhenate
- Physical state: Crystalline solid
- Analytical purity: Minimum 99.9%

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Test system

Vehicle:

unchanged (no vehicle)

Controls:

other: Untreated eye served as control

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied: 3 mg

Duration of treatment / exposure:

Readings are made generally at 1, 24 and 48 hours after instillation of test material according to Draize. The published paper indicates that readins were made up to 72 hours. Material is not removed from the eye following instillation.

Observation period (in vivo):

Generally up to 48 hours according to Draize. Readings can be made after 96 hours if residual injury is present. The published paper indicates that readins were made up to 72 hours.

Number of animals or in vitro replicates:

Two

Results and discussion

In vivo

Results

Irritation parameter:

other: Not irritating

Remarks on result:

other: No detectable damage to the cornea, iris, or conjunctiva

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: other: Presumably based on Draize scores

Conclusions:

Potassium perrhenate, when applied to one eye of each of two rabbits, was described as causing no detectable damage to the cornea, iris, or conjunctiva throughout the 72-hr observation period.

Executive summary:

A brief published paper describes an eye irritation study in rabbits using the method of Draize et al. (1944). Potassium perrhenate (3 mg) was applied (presumably as a crystalline solid) to one eye of each of two rabbits. The untreated eye served as the control. No detectable damage to the cornea, iris, or conjunctiva was reported during an observation period of 72 hours.