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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not given
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Published paper with little experimental detail. But data appears to be scientifically acceptable.

Data source

Reference
Reference Type:
publication
Title:
Pharmacology and toxicology of potassium perrhenate and rhenium trichloride
Author:
Haley T.J. and Catwright F.D.
Year:
1968
Bibliographic source:
Journal of Pharmaceutical Sciences Vol 57 (No. 2), 321-323

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Acute toxicity by the intraperitoneal route was determined in mice.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium perrhenate
EC Number:
233-953-8
EC Name:
Potassium perrhenate
Cas Number:
10466-65-6
Molecular formula:
K.O4Re
IUPAC Name:
Potassium oxido(trioxo)rhenium
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): Potassium perrhenate
- Physical state: Presumably in solution
- Analytical purity: 99.9%

Test animals

Species:
mouse
Strain:
CF-1
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 21 - 34 g

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
2 800 mg/kg bw
Based on:
test mat.
Remarks on result:
other: range 2500 - 3050 mg/kg bw
Clinical signs:
Toxic symptoms were sedation and severe ataxia with death or recovery within 7 days. No convulsions were observed.

Applicant's summary and conclusion

Conclusions:
The LD50 (7 days) for mice given potassium perrhenate by the intraperitoneal route was reported as 2800 mg/kg bw (range 2500 - 3050 mg/kg bw)
Executive summary:

A brief published paper describes an acute toxicity study in mice treated by the intraperitoneal route. An unspecified number of male CF-1 mice, weighing 21 - 34 g, were administered potassium perrhenate (minimum purity 99.9%) and observed for 7 days. The LD50 was reported as 2800 mg/kg bw, with a range of 2500 - 3050 mg/kg bw. Toxic symptoms were sedation and severe ataxia with death or recovery within 7 days. No convulsions were observed.