Registration Dossier
Registration Dossier
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EC number: 256-283-8 | CAS number: 46830-22-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Although no experimental data is available, the substance belongs to a chemical category for which the toxicokinetics has been well studied. Quaternary ammonium cations, are positively charged polyatomic ions of the structure N(CH3)3R+, R being an acrylic ester or ether group. Unlike primary, secondary, or tertiary ammonium cations, members of this category of quaternary ammonium cations are permanently charged, independent of the pH of their solution. Unlike the tertiary ammonium congeners, they are not corrosive and have only low to moderate toxicity. Since the molecule is a highly charged cation, it will be very poorly absorbed. Cytochome p-450 is not effective with highly soluble, highly charged molecules. Any absorbed fraction will be rapidly excreted through glomerular filtration as these highly charged molecules will not be reabsorbed in the descending renal tubules. Subsequently, very little metabolism will take place.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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