Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
bioaccumulation in aquatic species, other
Data waiving:
other justification
Justification for data waiving:
other:

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
3-icosyl-4-henicosylidene-2-oxetanone
EC Number:
401-210-9
EC Name:
3-icosyl-4-henicosylidene-2-oxetanone
Cas Number:
83708-14-9
Molecular formula:
C44H84 O2
IUPAC Name:
(4Z)-4-henicosylidene-3-icosyloxetan-2-one

Test organisms

Details on test organisms:
Lepomis macrochirus

Study design

Route of exposure:
aqueous
Test type:
flow-through

Test conditions

Test temperature:
Test (solution) temperature: 21 °C (min.) ... 23 °C (max.)
Details on test conditions:
Duration of test: 28 d
Nominal and measured concentrations:
Concentration of test material used:

Results and discussion

Bioaccumulation factor
Type:
BCF
Value:
71 L/kg
Details on results:
Steady state depuration period: 21 d; no. of samples:

Applicant's summary and conclusion

Validity criteria fulfilled:
no
Conclusions:
The BCF for fish is experimentally determined to be < 71 l/kg, according to SNIF submitted to Belgium Competent Authority. However during the PBT sub-group meeting in April 2006, it was assumed that the result of this test could be invalid since the use of a dispersant may not have been appropriate.
The calculated log Kow of 19.1 (QSAR, Kowwin) seems extreme, but is supported by the substance low aqueous solubility. Substance with such extreme log Kow are thought not to bioconcentrate because of their bio-unavailability due to very strong sorption to organic matter. The is reflected in QSARs for BCF, e.g. the EPIWIN QSAR levels the log BCF predictions down to 0.5 for substances with very high log Pow, including shorter-chain AKD (C12/C16, expected log Kow 11-15) as well as PMC D-532 (BCF of 3). In contrast to this, the EU TGD polynominal QSAR equation for log BCF as a function of log Kow (> 6) predicts a decrease of BCF from logKow = 6.6 (log BCF = 4.6) up to log Kow = 11.5 (log BCF = 1), followed by a very steep increase due to the highest (4th) power term in the equation. This increase leads to very high expected log BCF for the shorter-chain AKD as well as for PMC D-532, but is unrealistic and presumably outside the intended application range of the equation.
The EPIWIN estimate (BCF = 3 l/kg wwt) is considered reliable.