Registration Dossier
Registration Dossier
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EC number: 601-577-7 | CAS number: 118969-29-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-[(2E)-2-benzylidenehydrazino]-4-sulfonatobenzoate, disodium salt
- EC Number:
- 601-577-7
- Cas Number:
- 118969-29-2
- Molecular formula:
- C14H10N2Na2O5S
- IUPAC Name:
- 3-[(2E)-2-benzylidenehydrazino]-4-sulfonatobenzoate, disodium salt
- Test material form:
- other: solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Controls:
- other: The right eye remained untreated and served as a control.
- Observation period (in vivo):
- 1,24,48,72 h
- Number of animals or in vitro replicates:
- The present study was started with one single animal. Because only slight reactions were observed, two extra rabbits were added to the test later.
Results and discussion
Any other information on results incl. tables
Under the experimental conditions employed substance induced reactions of the cornea, iris, and conjunctiva when instilled into the conjunctival sac of albino rabbits' eyes. Because the mean values of the readings 24 to 72 hours after instillation are below the threshold of significance, the substance can be classified as non-irritant according to the Commission Directive 83/467/EEC.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: 83/467/EEC
- Conclusions:
- not irritating
- Executive summary:
No adverse effect observed (not irritating)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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