Registration Dossier
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EC number: 935-721-8 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
No bioaccumulation data is available for the target substance itself, phenol, styrenated, epoxidised [EC no. 935-721-8]. Distyrenated phenol containing a 2,4-bis(1-phenylethyl)phenol, a key component of the epoxidised form, did not exhibit a bioaccumulating potential in a fish feeding study due to rapid excretion while no BCF was derivable (see NOACK 2008). In a study according to OECD TG 305 using the supporting substance cumylphenol, a structure-related mono-methylstyrenated phenol, BCF values between 69 and 190 were determined. The highest value is taken to characterise the bioaccumulation potential of phenol, styrenated, epoxidised.
Key value for chemical safety assessment
- BCF (aquatic species):
- 190 dimensionless
Additional information
Two experimental studies were identified providing data to assess the bioaccumulation potential of phenol styrenated. In one study, a structure-related mono-methylstyrenated substance, cumylphenol [4 -(1 -methyl-1 -phenylethyl)phenol)] was tested according to OECD TG 305. The BCF values determined were in the range between 65 and 190. In a second study, a mixture of distyrenated and tristyrenated phenol (40 and 60% w/w, respectively) was applied in a fish feeding study (uptake phase 10 days, depuration phase 42 days). A BCF/BMF could not be established, as the test substance concentration for distyrenated phenol in fish decreased below limit of detection already during the second half of the uptake phase (after day 5). Results of both studies indicate that the bioaccumulation potential of phenol, styrenated, the precursor of the target substance, is low. It is assumed that - based on the close similarity of the chemical structures and polarity - this also holds for the reaction product, phenol, styrenated, epoxidised. After enzymic hydrolysis, the target substance may easily be conjugated by GSH, UDP-glucuronate or sulphate and be excreted.
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