Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
fertility, other
Remarks:
based on test type (migrated information)
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1946
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: read across substance, very briefly documented, insufficient information on test material, purity and diet

Data source

Reference
Reference Type:
publication
Title:
Effects of Massive Doses of P-Aminobenzoic Acid and Inositol on Reproduction in the Rat
Author:
B. Ershoff
Year:
1946
Bibliographic source:
Proc Soc Exp Biol Med 1946, 63:479-480

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Reference substance name:
p-aminobenzoic acid
IUPAC Name:
p-aminobenzoic acid

Test animals

Species:
rat
Strain:
Long-Evans
Sex:
female
Details on test animals or test system and environmental conditions:
age: 23d
weight: 41.8 g
diet: 6 different diets not further specified, ad libitum

Administration / exposure

Route of administration:
oral: unspecified
Details on mating procedure:
females were weighed weekly, and vaginal smears were taken daily from the 48th day
after the 60th day the animals were bred to males of proven fertility
Doses / concentrations
Remarks:
Doses / Concentrations:
1%
Basis:
nominal in diet

Results and discussion

Results: P0 (first parental generation)

Reproductive function / performance (P0)

Reproductive performance:
no effects observed

Details on results (P0)

No adverse effects on growth or reproduction were noted in female rats fed purified rations containing 1% p-amino-benzoic acid or inositol. Lactation was inadequate both in control and experimental rations, although some young were weaned on each of the above diets.

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion