Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Guideline:
other: Buehler
GLP compliance:
yes
Type of study:
patch test
Species:
guinea pig
Strain:
Hartley
Positive control substance(s):
yes
Remarks:
dinitrochlorobenzene
Reading:
other: skin sensitisation score
Hours after challenge:
48
Group:
test chemical
Dose level:
see attached full study report
No. with + reactions:
20
Total no. in group:
20
Clinical observations:
See attached full study report
Remarks on result:
other: Reading: other: skin sensitisation score. . Hours after challenge: 48.0. Group: test group. Dose level: see attached full study report. No with. + reactions: 20.0. Total no. in groups: 20.0. Clinical observations: See attached full study report.
Interpretation of results:
sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
To be classified as sensitising
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

The substance must be classified as sensitising category 1 (with H317: may cause an allergic skin reaction)