Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992

Materials and methods

Test guideline
Guideline:
other: no data
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Di(tert-butyl) carbonate
EC Number:
246-240-1
EC Name:
Di(tert-butyl) carbonate
Cas Number:
24424-99-5
Molecular formula:
C10H18O5
IUPAC Name:
di-tert-butyl carbonate

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
No. of animals per sex per dose:
5 (5 male plus 5 female dosed at 80/120/180 mg/m3 measured)

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
100 mg/m³ air
Based on:
test mat.
Remarks:
measured concentrations
Exp. duration:
4 h

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category I
Remarks:
Migrated information Criteria used for interpretation of results: EU