Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 443-050-2 | CAS number: 120903-40-4 PERFLUOROHEXANE NITRILE VINYL ETHER
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
Water solubility of the hydrolysis product is 4.68 mg/L at 20 °C (OECD 105)
Key value for chemical safety assessment
- Water solubility:
- 4.68 mg/L
- at the temperature of:
- 20 °C
Additional information
MV5CN is hydrolytically active. The water solubility of the hydrolysis product MV5CN amide was determined using a column elution method according to OECD Guideline 105 (Water Solubility). A measured quantity of test materials was prepared in acetone. The solution was mixed with LiChroprep Si 60 25-40 µm column material. Acetone was completely evaporated at 40 °C. The loaded carrier material was stored overnight at room temperature. A 150 mmx4.6 mm i.d column was filled with the carrier material and enclosed with 2 µm frits. The column was completely filled with double distilled water and allowed to equilibrate for two hours. The column system was subsequently stabilized overnight using a flow rate of 24 mL/hour. The column was then eluted with double distilled water at a flow rate of 24 mL/hour and ten consecutive samples of 1 mL were taken. The flow rate was halved to 12 mL/hour and ten consecutive samples of 1 mL were taken. A 10 µL aliquot from each sample were diluted 100 times with 50/50(v/v) acetonitrile/water and analyzed using Ultra performance liquid chromatography/Tandem mass spectrometer (UPLC-MS/MS). The test material has measured water solubility of 4.68 mg/L at 20 °C.
This is a guideline study conducted under GLP compliance. Therefore, it is considered reliable without restriction.
An additional study was performed on the parent MV5CN according to OECD 105, but was unable to detect that parent at the limit of detection (<0.4 mg/L). Although a guideline study compliant with GLP criteria, it is considered reliable with restrictions due to the analytical shortcomings. Moreover, due to lack information gained from the study, data adequacy is considered to be other information.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
