Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1)

Endpoint summary

Description of key information

An assessment of the hydrolysis of Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) was performed based on the behaviour of the individual constituents of the substance. The assessment concluded that is likely that the substance will be stable to hydrolysis under pH and temperature conditions of physiological and environmental relevance.

 

An expert assessment of the adsorption/desorption potential of Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1) was performed based on the physico-chemical properties of the constituents of the substance. A substance is regarded as having the potential for adsorption if it has a Log Koc or Log Kow ≥3. The organic constituents of Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1), in their ionised and un-ionised forms have Log Koc and/or Log Kow values that are below the adsorption trigger value of 3. The substance is expected to have a low potential for adsorption and, therefore, additional adsorption-desorption data is not required under REACH Annex VIII. Any sorption of Reaction mass of morpholine and 6-[(p-tosyl)amino]hexanoic acid, compound with morpholine (1:1)] to soil or sediment is expected to be negligible.

 

The ready biodegradation of the test substance was determined in a biological oxygen demand (BOD), GLP-certified test undertaken in accordance with OECD Guideline 306 (Biodegradability in Seawater).

The aim of the OECD 306 test is to establish the biodegradability of an organic material in a marine environment. Natural seawater considered to be biologically active was acquired from North Wales and nutrient fortified for use as the study inoculum. The registration substance at 2.5 and 3.0 mg/l, sodium benzoate at 2.5 mg/l (as a reference material to monitor microbial activity), and a seawater only blank were maintained at 17.5 - 20.5°C in the dark and reviewed on day 0, 3, 7, 14, 21, and 28. Measurement for oxygen was taken in the form of DOC at the time intervals specified and COD calculated. DOC and COD were used to determine percentage (%) biodegradability of the test material. The % biodegradation of sodium benzoate was reported to be 71.9 % over the 28-day study duration, indicating a biologically active inoculum, with a DOC of 3.83 mgO2/L. COD for the test substance was found to be 1.571 mg/mg. By the end of the experiment on Day 28, the test substance at 2.5 and 3.0 mg/l had been biodegraded by 26.2 and 19.5% (5.81 and 5.87 mgO2/L), respectively. It can be concluded that the substance is not ready biodegradable.