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Diss Factsheets

Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study without deviation
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
other: modified due to complete miscibility of the test item with water
Water solubility:
>= 1 000 g/L
Temp.:
20 °C
pH:
8.5 - 8.56
Remarks on result:
other: The test item is completely miscible with water in the tested concentration (5 g + 5 mL water)

Preliminary test

Samples of the test item were prepared in purified water. The mixtures were shaken for ten minutes on a shaking machine and the dissolution behavior was checked.

 

 

 

Amount of test item [g]

Volume of water [mL]

Visual observation

Pre-sample 1

1.03256

1

not completely dissolved

Pre-sample 2

1.01551

2

not completely dissolved

Pre-sample 3

1.00728

3.5

completely dissolved

Pre-sample 4

1.01826

5

completely dissolved

Pre-sample 5

5.09253

5

not completely dissolved

 

Pre-sample 5 was additionally incubated for 24 hours at 30 °C under an incubation hood and then equilibrated for 24 hours at 20 °C in a thermostat. After this, the sample was completely dissolved and clear.

The test item was completely dissolved in the pre-sample 5. Therefore the test item was expected to be completely miscible with water and the water solubility was expected to be > 50 %

Due to these facts the procedure for the main test according to the OECD Guideline was modified.

 

 

Main test

 

Two samples were prepared containing approx. 5 g of the test item (see table below) and 5.0 mL of purified water. The samples were shaken for 24 hours at 30 °C and then incubated at 20 °C for 24 hours inside of a thermostat.

After this period the water solubility was checked manually. No phase separation was observed; the samples were clear. The test item was completely dissolved in the samples.

 

Sample no.

Amount of test item [g]

Volume of water added [mL]

Incubation time at 20 °C [h]

pH value1)

1

5.04992

5

24

8.56

2

5.05569

5

24

8.50

 

1)The purified water used for the tests had a pH value of 7.27

 

The results showed that the test item is in the tested concentration under the conditions of the test completely miscible with water.

Conclusions:
The results showed that the test item is in the tested concentration under the conditions of the test completely miscible with water.
Executive summary:

The water solubility of the substance was determined according to OECD Guideline 105 employing a modified flask method

Water solubility (at 20 °C):

The substance is under the conditions of the test and in the tested concentration (5 g + 5 mL water) completely miscible with water.

Description of key information

The substance is under the conditions of the test and in the tested concentration (5 g + 5 mL water) completely miscible with water.

Key value for chemical safety assessment

Water solubility:
1 000 000 mg/L
at the temperature of:
20 °C

Additional information