Copper, [29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, [[3-(dimethylamino)propyl]amino]sulfonyl derivs., acetates

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From January 28th to February 05th, 2016

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Remarks:

Deviations from test guidelines occurred and do not permit to follow the guideline procedures.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

as revised in 1997

Deviations:

yes

Remarks:

deviations do not permit to follow the guideline procedures

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

yes

Remarks:

deviations do not permit to follow the guideline procedures

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Water solubility:

ca. 150 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

150 g/L

Incubation duration:

3 d

Temp.:

20 °C

Remarks on result:

other: it is not possible to determine absolute test substance water solubility by flask method; however, based on microscopy observetion the mixtures were homogeneous in all flasks.

Details on results:

Afier three days of shaking the mixtures had very viscous almost pasty consistency. Mixtures practically did not flow. Therefore it was not possible to shake or stir the mixtures. Undissolved surplus of the test substance was not found. Based on the microscopy observation the mixtures were homogeneous in all flasks. It was confirmed that all test substance was dissolved in solvent, therefore saturated solutions were not prepared. However, it was not possible to continue in further testing. Due to properties of the test substance mixtures it was not possible to fulfilled A.6 method and OECD Test Guideline No 105 conditions.
It is not possible to determine absolute test substance water solubility by flask method due to the high viscosity of the test substance mixture with water. Mixtures practically did not flow. lt was not possible to shake or stir the mixtures.Expected solubility in water should be higher than 150 g/l.

PRELIMINARY TEST
The determined solubility is greater than 0.01 g/l. Therefore the flask method was chosen to the main test.

Conclusions:

Expected solubility in water should be higher than 150 g/l.

Executive summary:

Water solubility test was performed for the test substance. Flask method was used. Three flasks were used for test. 30.00 g of the test substance was weighed into each one of three stoppered glass flasks. The volume of 200 ml of double distilled water was added into each of them. The glass vessels were tightly closed with glass stoppers and shaken in a shaking water bath at the temperature of 30° C within one, two and three days. After the shaking had been finished, the solutions were tempered down to 20 ± 0.1 °C for a period 24 hours. Afier three days of shaking the mixtures had very viscous almost pasty consistency. It was not possible to determine absolute test substance water solubility by flask method due to the high viscosity of the test substance mixture with water. Mixtures practically did not flow. lt was not possible to shake or stir the mixtures.

Expected solubility in water should be higher than 150 g/l.

Conclsuion

The water solubility of the test substance established by the flask method is higher than 150 g/l.

Description of key information

Expected solubility in water should be higher than 150 g/l.

Key value for chemical safety assessment

Water solubility:

150 g/L

at the temperature of:

20 °C

Additional information

Flask method - It was not possible to determine absolute test substance water solubility by flask method due to the high viscosity of the test substance mixture with water. Mixtures practically did not flow. It was not possible to shake or stir the mixtures.