Registration Dossier
Registration Dossier
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EC number: 275-063-2 | CAS number: 70955-74-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Bacterial Gene Mutation (Ames Test)
In a reliable OECD Guideline 471 GLP study, TiTDP was not mutagenic to any of 5 strains of S. typhimurium when tested in the absence and presence of an exogenous metabolic activation system (rat liver S9) at concentrations up to those producing cytoxicity.
Mammalian Gene Mutation
No effects in a new OECD Guideline 476 study on TiTDP.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Description of key information
Chromosomal Aberration (Mouse Micronucleus)
In a reliable OECD 474 Guideline GLP study (Gaikwad, 2014), TiTDP did not cause micronucleus induction in male and female mice when administered at a limit dose of 2000 mg/kg bw by gavage for two consecutive days.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
All available genetic toxicity study results are negative on closely related analogs. Test results are available for TiTDP in in vitro bacterial and mammalian agene mutation and in vivo chromosome aberration studies and also for TDP.
Justification for classification or non-classification
All available genetic toxicity study results are negative. Therefore, it is concluded that TiTDP is not genotoxic and does not warrant classification for mutagenicity.
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