Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-837-3 | CAS number: 75-08-1
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 11 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 276.4 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- No repeat dose toxicity data were available for ethanethiol. However, a key read across study (Ulrich, 1982) was available for butane-1-thiol. Both butane-1-thol and ethanethiol are members of the C2-C4 aliphatic thiols category. In this 90-day inhalation study, the repeated dose toxicity of butane-1-thiol was investigated in Sprague-Dawley rats. The NOAEC was identified to be 550 mg/m3 based on the absence of systemic toxicity effects at the highest concentration tested.
- AF for dose response relationship:
- 1
- Justification:
- ECHA default
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA default (subchronic to chronic)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA default
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA default (remaining differences)
- AF for intraspecies differences:
- 5
- Justification:
- ECHA default (workers)
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA default
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA default
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.6 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 159.5 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- No dermal repeat dose toxicity data were available for ethanethiol. One oral read across study (MHLW, 2006; Klimisch score = 2) of 2 -methylpropane-2-thiol has been performed but not used in the derivation of this DNEL because the exposure period was subacute. Therefore, read across inhalation data (Ulrich, 1982) from butane-1-thiol was used by performing a route-to-route extrapolation. The NOAEC used was 550 mg/m3 based on the absence of systemic toxicity effects at the highest concentration tested..
- AF for dose response relationship:
- 1
- Justification:
- ECHA default
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA default (subchronic to chronic)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA default (rat to human)
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA default (remaining differences)
- AF for intraspecies differences:
- 5
- Justification:
- ECHA default (workers)
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA default
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA default
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Long-term exposure – Systemic effects:
1) Dermal DN(M)EL:
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.55 mg/L |
Step 2) Modification of starting point |
Conversion for units: 0.55 mg/L x 1000 = 550 mg/m3 |
Correction of rat inhalation NOAEC to rat dermal NOAEL – correction for respiratory volume and for difference in absorption rates |
NOAELrat: 159.5 mg/kg bw/day (= 550 x 0.29* x 1) Assumption: Based on ECHA guidance (Chapter R.8) no default factor was applied for differences in absorption in rats and humans and therefore absorption was assumed to be 100% via the dermal and inhalation route *Respiration rate in rats for 6 hour exposure |
Step 3) Assessment factors |
ECHA assessment factors used |
Interspecies (allometric scaling) |
4 (rat) |
Interspecies |
2.5 (for systemic effects) |
Intraspecies |
5 (for worker population) |
Exposure duration |
2 (for sub-chronic to chronic) |
Dose response |
1 |
Quality of database |
1 |
Total Assessment Factors |
100 |
Worker DNELlong-term for dermal route -Systemic |
1.6(= 159.5 x 1/(4 x 2.5 x 5 x 2 x 1 x 1)) |
2) Inhalation DN(M)EL:
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.55 mg/L |
| Step 2) Modification of starting point | Conversion for units:0.55mg/L x 1000 = 550 mg/m3 |
| Correction of exposure duration in study | (6 hrs/day, 5 days/week) to default worker exposure (8 hrs/day, 5 days/ week) |
| Correction for activity driven differences of respiratory volumes in workers compared to workers in rest | 6.7 m3/10 m3Corrected NOAEC = 276.4 mg/m3(= 550 x 6/8 x 6.7/10) |
| Step 3) Assessment factors | ECHA assessment factors used |
| Interspecies | 2.5 (for systemic effects) |
| Intraspecies | 5 (for workers) |
| Exposure duration | 2 (for sub-chronic to chronic) |
| Dose response | 1 |
| Quality of database | 1 |
| Total Assessment Factors | 25 |
| Worker DNELlong-term for inhalation route -Systemic | 11 mg/m3 (= 276.4 x 1/(2.5 x 5 x 2 x 1 x 1)) |
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.96 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 98.2 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- No repeat dose toxicity data were available for ethanethiol. However, a key read across study (Ulrich, 1982) was available for butane-1-thiol, a structural analogue of ethanethiol. In this 90-day inhalation study, the repeated dose toxicity of butane-1-thiol was investigated in Sprague-Dawley rats. The NOAEC was identified to be 550 mg/m3 based on the absence of systemic toxicity effects at the highest concentration tested..
- AF for dose response relationship:
- 1
- Justification:
- ECHA default
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA default (subchronic to chronic)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- ECHA default
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA default (remaining differences)
- AF for intraspecies differences:
- 10
- Justification:
- ECHA default (general population)
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA default
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA default
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.8 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 159.5 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- No oral repeat dose toxicity data was available for ethanethiol. One key read across study (MHLW, 2006; Klimisch score = 1) of 2-methylpropane-2-thiol has been performed but not used in the derivation of this DNEL because it was a subacute study that only tested up to a maximum dose of 200 mg/kg bw/day and no adverse effects were recorded. Therefore in the absence of suitable oral data, key read across inhalation data (Ulrich, 1992) from butane-1-thiol (structural analogue) was used by performing a route-to-route extrapolation. The NOAEC used was 550 mg/m3 based on the absence of systemic toxicity effects at the highest concentration tested..
- AF for dose response relationship:
- 1
- Justification:
- ECHA default
- AF for differences in duration of exposure:
- 2
- Justification:
- ECHA default (subchronic to chronic)
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA default (rat to human)
- AF for other interspecies differences:
- 2.5
- Justification:
- ECHA default (remaining differences)
- AF for intraspecies differences:
- 10
- Justification:
- ECHA default (general population)
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA default
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA default
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Long-term exposure – Systemic effects:
2) Inhalation DN(M)EL:
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.55 mg/L |
| Step 2) Modification of starting point | Conversion for units: 0.55 mg/L x 1000 = 550 mg/m3 |
| Correction of exposure duration in study | (6 hrs/day, 5 days/week) to default general population exposure (24 hrs/day, 7 days/ week) Corrected NOAEC = 98.2 mg/m3(= 550 x 6/24 x 5/7) |
| Step 3) Assessment factors | ECHA assessment factors used |
| Interspecies | 2.5 (for systemic effects) |
| Intraspecies | 10 (for general population) |
| Exposure duration | 2 (for sub-chronic to chronic) |
| Dose response | 1 |
| Quality of database | 1 |
| Total Assessment Factors | 50 |
| General Population DNELlong-term for inhalation route -Systemic | 1.96 mg/m3 (= 98.2 x 1/(2.5 x 10 x 2 x 1 x 1)) |
3) Oral DN(M)EL:
Step 1) Relevant dose-descriptor |
NOAEC6h/rat: 0.55 mg/L |
| Step 2) Modification of starting point | Conversion for units: 0.55 mg/L x 1000 = 550 mg/m3 |
| Correction of rat inhalation NOAEC to rat oral NOAEL – correction for respiratory volume and for difference in absorption rates | NOAELrat:159.5 mg/kg bw/day (= 550 x 0.29 x 1) Assumption: Based on ECHA guidance (Chapter R.8) no default factor was applied for differences in absorption in rats and humans and therefore absorption was assumed to be 100% via the oral and inhalation route |
| Step 3) Assessment factors | ECHA assessment factors used |
| Interspecies (allometric scaling) | 4 (rat) |
| Interspecies | 2.5 (for systemic effects) |
| Intraspecies | 10 (for general population) |
| Exposure duration | 2 (for sub-chronic to chronic) |
| Dose response | 1 |
| Quality of database | 1 |
| Total Assessment Factors | 200 |
| General Population DNELlong-term for oral route -Systemic | 0.8 mg/kg bw/day (= 159.5 x 1/(4 x 2.5 x 10 x 2 x 1 x 1)) |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
